tert-butyl(3S,5R)-5-((N-hydroxyformamido)methyl)-2-methyl-4-oxononan-3-ylcarbamate | 1267585-49-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl(3S,5R)-5-((N-hydroxyformamido)methyl)-2-methyl-4-oxononan-3-ylcarbamate
• 英文别名: tert-butyl N-[(3S,5R)-5-[[formyl(hydroxy)amino]methyl]-2-methyl-4-oxononan-3-yl]carbamate
• CAS: 1267585-49-8
• 化学式: C₁₇H₃₂N₂O₅
• 分子量: 344.451
• InChiKey: MSIVDKFUBKQNNI-KGLIPLIRSA-N

物化性质

• 密度：
  1.070±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  95.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-{(1S,3R)-3-[(benzyloxyformylamino)methyl]-1-isopropyl-2-oxo-heptyl}carbamic acid t-butyl ester 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 tert-butyl(3S,5R)-5-((N-hydroxyformamido)methyl)-2-methyl-4-oxononan-3-ylcarbamate
  参考文献：
  名称：

  Peptide deformylase inhibitors with non-peptide scaffold: Synthesis and structure–activity relationships

  摘要：

  Peptide deformylase (PDF), which removes the formyl group at the N-terminal methionine residue of nascent protein, has been recognized as a potent target for antibacterial therapy. We report herein the synthesis and structure-activity relationship studies of non-peptide PDF inhibitors. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.11.056

文献信息

• Peptide deformylase inhibitors with non-peptide scaffold: Synthesis and structure–activity relationships
  作者：Seung Kyu Lee、Kwang Hyun Choi、Sang Jae Lee、Jong Sun Lee、Ji Yun Park、B. Moon Kim、Bong Jin Lee

  DOI：10.1016/j.bmcl.2010.11.056

  日期：2011.1

  Peptide deformylase (PDF), which removes the formyl group at the N-terminal methionine residue of nascent protein, has been recognized as a potent target for antibacterial therapy. We report herein the synthesis and structure-activity relationship studies of non-peptide PDF inhibitors. (C) 2010 Elsevier Ltd. All rights reserved.