2-(acetylamino)-2-[4-(acetyloxy)butyl]propanedioic acid, diethyl ester | 167305-83-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(acetylamino)-2-[4-(acetyloxy)butyl]propanedioic acid, diethyl ester
• 英文别名: diethyl 2-acetamido-2-(4-acetyloxybutyl)propanedioate
• CAS: 167305-83-1
• 化学式: C₁₅H₂₅NO₇
• 分子量: 331.366
• InChiKey: XBYDASXRJJPJAT-UHFFFAOYSA-N

物化性质

• 沸点：
  464.0±45.0 °C(Predicted)
• 密度：
  1.132±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  23
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-(acetylamino)-2-[4-(acetyloxy)butyl]propanedioic acid, diethyl ester 在 盐酸 、 lithium hydroxide 、 sodium hydroxide 、 porcine kidney acylase 作用下， 以 乙醇 为溶剂， 反应 30.5h， 生成 L-6-羟基正亮氨酸
  参考文献：
  名称：

  Dual Metalloprotease Inhibitors:  Mercaptoacetyl-Based Fused Heterocyclic Dipeptide Mimetics as Inhibitors of Angiotensin-Converting Enzyme and Neutral Endopeptidase

  摘要：

  A series of 7,6- and 7,5-fused bicyclic thiazepinones and oxazepinones were generated and incorporated as conformationally restricted dipeptide surrogates in mercaptoacyl dipeptides. These compounds are potent inhibitors of angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) both in vitro and in vivo. Compound 1a, a 7,6-fused bicyclic thiazepinone, demonstrated excellent blood pressure lowering in a variety of animal models characterized by various levels of plasma renin activity and significantly potentiated urinary sodium, ANP, and cGMP excretion in a cynomolgus monkey assay. On the basis of its potency and duration of action, compound 1a (BMS-186716) was advanced into clinical development for the treatment of hypertension and congestive heart failure.

  DOI：

  10.1021/jm970041e
• 作为产物：
  描述：

  乙酰氨基丙二酸二乙酯 以98的产率得到2-(acetylamino)-2-[4-(acetyloxy)butyl]propanedioic acid, diethyl ester
  参考文献：
  名称：

  Drugs of the Future 1999, 24, 269-277

  摘要：

  DOI：

文献信息

• Compounds containing a fused bicycle ring and processes therefor
  申请人：Bristol-Myers Squibb Company

  公开号：US05508272A1

  公开（公告）日：1996-04-16

  Compounds of the formula ##STR1## wherein X is O or S--(O).sub.t ; n is one or two; m is zero or one; Y is CH.sub.2, O, or S--(O).sub.t provided that Y is O or S--(O).sub.t only when m is one; and A is ##STR2## are dual inhibitors of NEP and ACE. Compounds wherein A is ##STR3## are selective ACE inhibitors. Also disclosed are methods of preparation and intermediates.

  式为##STR1##的化合物，其中X为O或S--(O).sub.t；n为一或二；m为零或一；Y为CH.sub.2、O或S--(O).sub.t，前提是当m为一时，Y仅为O或S--(O).sub.t；A为##STR2##的双重NEP和ACE抑制剂。其中A为##STR3##的化合物是选择性ACE抑制剂。还公开了制备方法和中间体。
• Process for preparing homocystein analogs useful as intermediates for
  申请人：Bristol-Myers Squibb Co.

  公开号：US05616775A1

  公开（公告）日：1997-04-01

  Homocysteine analogs of the formula ##STR1## wherein P.sub.1 is a nitrogen protecting group and R.sub.6 is alkyl, substituted alkyl or benzyl are prepared by esterifying N-protected L-methionine, oxidizing, treating the resulting sulfoxide with an acid anhydride, treating the resulting product with an alkali metal hydroxide followed by removal of formaldehyde and the treatment with an acid anhydride or acid halide. The L-homocysteine analogs are useful as intermediates in the preparation of compounds containing a fused bicyclic ring.

  本发明提供了一种公式为##STR1##的同型半胱氨酸类似物，其中P.sub.1是氮保护基，R.sub.6是烷基，取代烷基或苄基，通过酯化N-保护的L-甲硫氨酸，氧化，用酸酐处理所得的亚砜，用碱金属氢氧化物处理所得的产物，随后除去甲醛并用酸酐或酸卤化物处理。L-同型半胱氨酸类似物在制备含有融合双环环的化合物的中间体中有用。
• Process for preparing compounds containing a fused bicyclic ring
  申请人：Bristol-Myers Squibb Co.

  公开号：US05627278A1

  公开（公告）日：1997-05-06

  A process for preparing compounds of the formula ##STR1## wherein X is O or S; n is one or two; m is zero or one; Y is CH.sub.2, O, or S provided that Y is O or S only when m is one; and A is ##STR2## is disclosed. Also disclosed are processes for preparing the corresponding amino intermediates.

  本发明揭示了一种制备式为##STR1##的化合物的方法，其中X为O或S；n为一或二；m为零或一；Y为CH.sub.2、O或S，但当m为一时，Y仅为O或S；而A为##STR2##。本发明还揭示了制备相应氨基中间体的方法。
• Process for preparing amino acid esters useful as intermediates for
  申请人：Bristol-Myers Squibb Co.

  公开号：US05670699A1

  公开（公告）日：1997-09-23

  Amino acid esters of the formulas ##STR1## wherein m is zero or one and R.sub.3 is an acid protecting group are prepared. These amino acid esters are useful as intermediates in the preparation of fused bicyclic ring compounds.

  制备了化学式为##STR1##的氨基酸酯，其中m为零或一，R.sub.3为酸保护基团。这些氨基酸酯在制备融合双环环化合物的中间体中有用。
• Compounds containing a fused bicycle ring
  申请人：Bristol-Myers Squibb Co.

  公开号：US05672599A1

  公开（公告）日：1997-09-30

  Compounds of the formula ##STR1## wherein X is O or S--(O).sub.t ; n is one; m is zero or one; Y is CH.sub.2, O, or S--(O).sub.t provided that Y is O or S--(O).sub.t only when m is one; and A is ##STR2## are dual inhibitors of NEP and ACE. Compounds wherein A is ##STR3## are selective ACE inhibitors. Also disclosed are methods of preparation and intermediates.

  公式为##STR1##的化合物，其中X为O或S--(O).sub.t; n为1；m为0或1；Y为CH.sub.2，O或S--(O).sub.t，仅当m为1时，Y为O或S--(O).sub.t；A为##STR2##的化合物是NEP和ACE的双重抑制剂。其中A为##STR3##的化合物是选择性ACE抑制剂。还公开了制备方法和中间体。