1,3–di(tetrazol-1-yl)propan-2-ol | 956022-66-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,3–di(tetrazol-1-yl)propan-2-ol
• 英文别名: 1,3-bis(tetrazol-1-yl)-2-propanol
• CAS: 956022-66-5
• 化学式: C₅H₈N₈O
• 分子量: 196.172
• InChiKey: ZAUURHLRIZGOSU-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  iron(II) tetrafluoroborate hexahydrate 、 1,3–di(tetrazol-1-yl)propan-2-ol 、 乙腈 以 乙腈 为溶剂， 以10%的产率得到
  参考文献：
  名称：

  A 2D [FeII-bistetrazole] coordination polymer exhibiting spin-crossover properties

  摘要：

  The reaction of 1,3-bis(tetrazol-1-yl)-2-propanol (btzpol) with Fe(BF4)(2) center dot 6H(2)O in acetonitrile yields the remarkable 2D coordination polymer [Fe-II(btzpol)(1.8)(btzpol-OBF3)(1.2)](BF4)(0.8) center dot (H2O)(0.8)(CH3CN) (1). This compound has been structurally characterized using an X-ray single-crystal synchrotron radiation source. The iron(11) centers are bridged by means of double btzpol bridges along the c direction, and by single btzpol bridges along the b direction. The reaction of part of the ligand with the counterion has forced the compound to crystallize in this extended two dimensional structure. The compound shows spin-transition properties, both induced by temperature and light, with T-1/2 = 112 K and T(LIESST) = 46 K, respectively. The relaxation of the metastable high-spin state created by irradiation is exponential, following an Arrhenius type behavior at high temperature, and dominated by a temperature independent tunneling process at lower temperatures. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2006.12.010

文献信息

• Synergic Effect of Phthalide Lactones and Fluconazole and Its New Analogues as a Factor Limiting the Use of Azole Drugs against Candidiasis
  作者：Piotr Krężel、Teresa Olejniczak、Aleksandra Tołoczko、Joanna Gach、Marek Weselski、Robert Bronisz

  DOI：10.3390/antibiotics11111500

  日期：——

  or thiophene-2-carboxylic acid chlorides or with adipic acid. In structures 11 and 12 the hydroxyl group was replaced with the fragment -CH2Cl or = CH2. Additionally, the difluorophenyl ring was replaced with unsubstituted phenyl. The structures of the obtained compounds were determined by 1H NMR, and 13C NMR spectroscopy. Molecular masses were established by GC-MS or elemental analysis. The MIC50

  近年来，白色念珠菌和其他病原酵母菌对唑类抗真菌药物的耐药性迅速增加，是临床治疗中的一个重要问题。目前的药理学知识状况排除了唑类药物的撤回，因为尚未开发出其他活性物质可以有效替代它们。因此，抗酵母策略之一可能是依靠天然化合物和唑类药物的协同作用的疗法，限制唑类药物对抗念珠菌病的使用。体外进行的协同测定用于评估药物相互作用分数抑制浓度指数。氟康唑 ( 1 ) 和三种与芹菜植物中天然存在的合成内酯相同的协同作用 - 3-正丁基苯酞 ( 2 )、3-正亚丁基苯酞 ( 3 )、3-正丁基-4,5,6 ,7-四氢苯酞 ( 4 ) - 针对白色念珠菌ATCC 10231、白色念珠菌ATCC 2091 和吉里蒙念珠菌KKP 3390 的性能分别与各个化合物的性能进行了比较。氟康唑 ( 1 ) 的 MIC 90 （抑制酵母生长 90% 的抑菌物质的量（以 µg/mL 为单位））测定为 5.96–6.25 µg/mL，内酯2–4