1-isopropyl-2-methoxycarbonylaziridine | 30005-74-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-isopropyl-2-methoxycarbonylaziridine
• 英文别名: 1-isopropyl-aziridine-2-carboxylic acid methyl ester；1-Isopropyl-2-methoxycarbonyl-aziridin；Methyl-1-isopropyl-aziridin-carboxylat；2-Carbomethoxy-1-isopropyl-aziridin；N-isopropyl-2-carbomethoxy-ethylenimine；methyl 1-propan-2-ylaziridine-2-carboxylate
• CAS: 30005-74-4；31907-89-8
• 化学式: C₇H₁₃NO₂
• 分子量: 143.186
• InChiKey: VVQMHMZTGJHDNV-UHFFFAOYSA-N

物化性质

• 沸点：
  30-31 °C(Press: 1.5 Torr)
• 密度：
  1.068±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  29.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-isopropyl-2-methoxycarbonylaziridine 在 盐酸 作用下， 以 乙醚 为溶剂， 生成 α-Chlor-β-isopropylaminopropionsaeuremethylester
  参考文献：
  名称：

  Wartski,L.; Wakselman,C., Bulletin de la Societe Chimique de France, 1972, p. 1478 - 1482

  摘要：

  DOI：
• 作为产物：
  描述：

  2,3-二溴丙酸甲酯 、 异丙胺 、 三乙胺 以77%的产率得到
  参考文献：
  名称：

  KOSTYANOVSKIJ R. G.; PROSYANIK A. V.; MARKOV V. I.; ZON I. A.; POLYAKOV A+, IZV. ANSSSR. CEP. XIM. , 1976, HO 7, 1559-1571

  摘要：

  DOI：

文献信息

• Esters and amides from aziridine 2-carboxylic acid salts
  作者：C. Lambert、H.G. Viehe

  DOI：10.1016/s0040-4039(00)88924-8

  日期：1985.1

  Potassium salts of aziridine-2-carboxylic acid derivatives are efficiently converted into esters of amides by reactions with alkyl halides, alkyl dihalides or by acylation with trimethylacetyl chloride followed by aminolyses.

  通过与烷基卤化物，烷基二卤化物反应或通过与三甲基乙酰氯酰化然后进行氨解反应，氮丙啶-2-羧酸衍生物的钾盐可有效地转化为酰胺的酯。
• Acid-Catalyzed Ring Opening of 2-Substituted Aziridines with Alcohols
  作者：Jacques Bodenan、Josette Chanet-Ray、Roger Vessiere

  DOI：10.1055/s-1992-26094

  日期：——

  Study of nucleophilic ring opening of various functionalized aziridines (2-alkoxycarbonyl, 2-hydroxymethyl, 2-cyano- and 2-aminomethyl) by alcohols in presence of diethyl ether-boron trifluoride complex.

  研究在二乙醚-三氟化硼络合物存在下，醇对各种官能化氮铱（2-烷氧基羰基、2-羟甲基、2-氰基和 2-氨基甲基）的亲核开环作用。
• Preparation of optically active aziridine carboxylates by lipase-catalyzed alcoholysis
  作者：Monique Martres、Gérard Gil、Alain Méou

  DOI：10.1016/s0040-4039(00)78498-x

  日期：1994.11

  Aziridine carboxylates alcoholysis by lipases depends of the N-substituent. N-alkyl and N-aryl compounds have been resolved with medium to good enantiomeric purity by enzymatic alcoholysis catalyzed by pig pancreatic (PPL) or Candida cylindracea lipase (CCL).

  氮丙啶通过脂肪酶使羧酸酯化取决于N-取代基。N-烷基和N-芳基化合物已通过猪胰腺（PPL）或圆柱形念珠菌脂肪酶（CCL）催化的酶解作用以中等至良好的对映体纯度拆分。
• ARYLMETHYLENE UREA DERIVATIVE AND USE THEREOF
  申请人：Ohno Michihiro

  公开号：US20100016319A1

  公开（公告）日：2010-01-21

  This invention relates to a pharmaceutical comprising as an effective ingredient an arylmethylene urea exemplified by the following formula: or a pharmaceutically acceptable salt thereof. The arylmethylene urea and the pharmaceutically acceptable salts thereof are useful for therapy or prophylaxis of inflammatory bowel disease and overactive bladder.

  本发明涉及一种药物，其有效成分为以下式子所示的芳基亚甲基脲或其药学上可接受的盐： 该芳基亚甲基脲及其药学上可接受的盐可用于治疗或预防炎症性肠病和过度活跃的膀胱。
• Synthesis and reactivity of 4-chloro-3,3,4-trifluoro-methoxycarbonyl cyclobutene (CTMC)
  作者：Marie-Aim�e Plancquaert、Zdenek Janousek、Heinz G. Viehe

  DOI：10.1002/prac.19943360106

  日期：——

  An improved synthesis of CTMC is described. This cyclobutene is thermally stable towards electrocyclic ring opening. Its reactivity is explored and a number of radical adducts are described. A more complicated picture is observed with various nucleophiles. The strong dienophilic character of CTMC is illustrated by numerous examples. CTMC reacts well as a dipolarophile with diphenylnitrone, diphenylnitrilimine and diazoalkanes. The high reactivity of this cyclobutene is due to its inherent polarity and strain.