4-ethynyltriisopropylsilyl-2,2,6,6-tetramethyl-3,4-dehydro-piperidine-1-oxyl | 369650-99-7

• 分子结构分类: 有机化合物
• 英文名称: 4-ethynyltriisopropylsilyl-2,2,6,6-tetramethyl-3,4-dehydro-piperidine-1-oxyl
• CAS: 369650-99-7
• 化学式: C₂₀H₃₆NOSi
• 分子量: 334.597
• InChiKey: DTBBUPGFBUIBDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.74
• 重原子数：
  23.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  23.14
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  4-ethynyltriisopropylsilyl-2,2,6,6-tetramethyl-3,4-dehydro-piperidine-1-oxyl 在 四(三苯基膦)钯 TEA 、 四丁基氟化铵 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  A SHORT PROCEDURE FOR SYNTHESIS OF 4-ETHYNYL-2,2,6,6-TETRAMETHYL-3,4-DEHYDRO-PIPERIDINE-1-OXYL NITROXIDE

  摘要：

  The spin-probe labeling technique has been applied to DNA and offers the possibility of studying antisense agents in cells. Simpler syntheses of spin-probes for incorporation into DNA would facilitate this. Here, we describe the synthesis of a new spin probe that requires half the number of steps of related 5 ring nitroxide.

  DOI：

  10.1081/scc-100104464
• 作为产物：
  描述：

  4-ethynyltriisopropylsilyl-4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl 在 氯化亚砜 作用下， 以 吡啶 为溶剂， 反应 3.0h， 以72%的产率得到4-ethynyltriisopropylsilyl-2,2,6,6-tetramethyl-3,4-dehydro-piperidine-1-oxyl
  参考文献：
  名称：

  A SHORT PROCEDURE FOR SYNTHESIS OF 4-ETHYNYL-2,2,6,6-TETRAMETHYL-3,4-DEHYDRO-PIPERIDINE-1-OXYL NITROXIDE

  摘要：

  The spin-probe labeling technique has been applied to DNA and offers the possibility of studying antisense agents in cells. Simpler syntheses of spin-probes for incorporation into DNA would facilitate this. Here, we describe the synthesis of a new spin probe that requires half the number of steps of related 5 ring nitroxide.

  DOI：

  10.1081/scc-100104464