1-Acetyl-4-(4-chlorophenyl)-3-(3,4,5-trimethoxyphenyl)imidazol-2-one | 1019974-35-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-Acetyl-4-(4-chlorophenyl)-3-(3,4,5-trimethoxyphenyl)imidazol-2-one
• CAS: 1019974-35-6
• 化学式: C₂₀H₁₉ClN₂O₅
• 分子量: 402.834
• InChiKey: RNOFTBIMGZJOEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  68.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,4,5-三甲氧基异氰酸苯酯 、 N-(2-(4-chlorophenyl)-2-oxoethyl)acetamide 以 甲苯 为溶剂， 反应 5.0h， 以76%的产率得到1-Acetyl-4-(4-chlorophenyl)-3-(3,4,5-trimethoxyphenyl)imidazol-2-one
  参考文献：
  名称：

  Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents

  摘要：

  A new series of aryl substituted imidazol-2-one derivatives structurally related to combretastatin A-4 (CA-4) were synthesized and evaluated for their cytotoxic activities in vitro against various human cancer cell lines including MDR cell line. The cytotoxic effects of compounds 7b and 7i proved to be similar to or greater than that of docetaxel. The highly active compound 7b also exhibited excellent inhibitory activity on tumor growth in vivo. (C) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2007.11.048

文献信息

• Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents
  作者：Na Xue、Xiaochun Yang、Rui Wu、Jing Chen、Qiaojun He、Bo Yang、Xiuyang Lu、Yongzhou Hu

  DOI：10.1016/j.bmc.2007.11.048

  日期：2008.3

  A new series of aryl substituted imidazol-2-one derivatives structurally related to combretastatin A-4 (CA-4) were synthesized and evaluated for their cytotoxic activities in vitro against various human cancer cell lines including MDR cell line. The cytotoxic effects of compounds 7b and 7i proved to be similar to or greater than that of docetaxel. The highly active compound 7b also exhibited excellent inhibitory activity on tumor growth in vivo. (C) 2008 Published by Elsevier Ltd.