3-(4-chlorophenyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-2-one | 61963-00-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(4-chlorophenyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-2-one
• 英文别名: 3-(4-chlorophenyl)-1H-imidazo[4,5-b]pyridin-2(3H)-one；3-(4-chloro-phenyl)-1,3-dihydro-imidazo[4,5-b]pyridin-2-one；3-(4-chlorophenyl)-1,3-dihydroimidazo[ 4,5-b] pyridin-2-one；3-(4-chlorophenyl)-1,3-dihydro-2H-Imidazo[4,5-b]pyridin-2-one；3-(4-chlorophenyl)-1H-imidazo[4,5-b]pyridin-2-one
• CAS: 61963-00-6
• 化学式: C₁₂H₈ClN₃O
• 分子量: 245.668
• InChiKey: KLHPWBJQCGZDKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-氨基-2-氯吡啶 、 对氯苯胺 、 尿素 以64%的产率得到3-(4-chlorophenyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-2-one
  参考文献：
  名称：

  Synthesis of 1-and 3-substituted imidazo[4,5-b]pyridin-2-ones

  摘要：

  1- and 3-Substituted imidazo[4,5-b]pyridin-2-ones were synthesized by heating equimolar amounts of 3-amino-2-chloropyridine or 2-chloro-3-methylaminopyridine, urea, and the corresponding arylamine at 150-210 degrees C. The reaction of 3-amino-2-chloropyridine with urea and p-phenylenediamine or p,p'-diaminobiphenyl at a ratio of 2:2:1 under analogous conditions gave 1,4-bis-(2-oxoimidazo[4,5-b]pyridin-3-yl)benzene or 1,4-bis(2-oxoimidazo[4,5-b]pyridin-3-yl)biphenyl, respectively.

  DOI：

  10.1134/s1070428006060145

文献信息

• US4144341A
  申请人：——

  公开号：US4144341A

  公开（公告）日：1979-03-13
• Synthesis of 1-and 3-substituted imidazo[4,5-b]pyridin-2-ones
  作者：Yu. M. Yutilov、N. N. Smolyar、D. A. Lomov

  DOI：10.1134/s1070428006060145

  日期：2006.6

  1- and 3-Substituted imidazo[4,5-b]pyridin-2-ones were synthesized by heating equimolar amounts of 3-amino-2-chloropyridine or 2-chloro-3-methylaminopyridine, urea, and the corresponding arylamine at 150-210 degrees C. The reaction of 3-amino-2-chloropyridine with urea and p-phenylenediamine or p,p'-diaminobiphenyl at a ratio of 2:2:1 under analogous conditions gave 1,4-bis-(2-oxoimidazo[4,5-b]pyridin-3-yl)benzene or 1,4-bis(2-oxoimidazo[4,5-b]pyridin-3-yl)biphenyl, respectively.