(R,E)-ethyl 4-(tert-butoxycarbonyl)oct-2-enoate | 1101136-44-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (R,E)-ethyl 4-(tert-butoxycarbonyl)oct-2-enoate
• CAS: 1101136-44-0
• 化学式: C₁₅H₂₇NO₄
• 分子量: 285.384
• InChiKey: GXRGEJJUJHYSCC-HCRIHEDKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.19
• 重原子数：
  20.0
• 可旋转键数：
  7.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  64.63
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (R,E)-ethyl 4-(tert-butoxycarbonyl)oct-2-enoate 在 10% Pd/C 、 氢气 作用下， 以 甲醇 为溶剂， 以99%的产率得到(R)-ethyl 4-(tert-butoxycarbonyl)octanoate
  参考文献：
  名称：

  Structure–activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A2 enzymes

  摘要：

  A variety of 2-oxoamides and related amides based on natural and non-natural amino acids were synthesized. Their activity on two human intracellular phospholipases (GIVA cPLA(2) and GVIA iPLA(2)) and one human secretory phospholipase (GV sPLA(2)) was evaluated. We show that an amide based on (R)-gamma-norleucine is a highly selective inhibitor of GV sPLA2. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.10.046
• 作为产物：
  描述：

  乙氧甲酰基亚甲基三苯基膦 、 2(R)-tert-butoxycarbonylaminohexanal 以 四氢呋喃 为溶剂， 反应 1.0h， 以0.23 g的产率得到(R,E)-ethyl 4-(tert-butoxycarbonyl)oct-2-enoate
  参考文献：
  名称：

  Structure–activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A2 enzymes

  摘要：

  A variety of 2-oxoamides and related amides based on natural and non-natural amino acids were synthesized. Their activity on two human intracellular phospholipases (GIVA cPLA(2) and GVIA iPLA(2)) and one human secretory phospholipase (GV sPLA(2)) was evaluated. We show that an amide based on (R)-gamma-norleucine is a highly selective inhibitor of GV sPLA2. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.10.046