2,4-diethyl-2,7-dimethyl-2,3-dihydro-1H-benzo[b][1,4]diazepine | 1429938-44-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 2,4-diethyl-2,7-dimethyl-2,3-dihydro-1H-benzo[b][1,4]diazepine
• CAS: 1429938-44-2
• 化学式: C₁₅H₂₂N₂
• 分子量: 230.353
• InChiKey: UAOIPDLTBLJQCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.46
• 重原子数：
  17.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  24.39
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  3,4-二氨基甲苯 、 丁酮 在 ZnPcOC₆F₅-APTES(at)SiO₂ 作用下， 反应 0.5h， 以92%的产率得到2,4-diethyl-2,7-dimethyl-2,3-dihydro-1H-benzo[b][1,4]diazepine
  参考文献：
  名称：

  Polyfluorinated–zinc(II)phthalocyanine complex immobilized on silica: A novel, highly selective and recyclable inorganic–organic hybrid catalyst for the synthesis of biologically important 1,5-benzodiazepines

  摘要：

  A novel, efficient and recyclable catalyst was prepared by covalent grafting of polyfluorinatedzinc(II)phthalocyanine complex onto functionalized silica gel. The activity of the catalyst was investigated for the solvent-free synthesis of 1,5-benzodiazepines at room temperature. The immobilized catalyst was characterized by elemental analysis (CHN), diffuse reflectance UV-Vis spectroscopy, solid-state C-13 CPMAS and Si-29 CPMAS NMR spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), BET surface area analysis, energy dispersive X-ray fluorescence (ED-XRF), Fourier transform Infrared (FT-IR) and atomic absorption spectroscopy (AAS) techniques. Short reaction time, mild reaction conditions, high turnover numbers, and easy recovery and reusability of the catalyst make this method a novel, economic and waste-free chemical process for the synthesis of biologically important 1,5-benzodiazepines. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.11.012