N-((2R,3R)-3-hydroxy-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Me)-OBn | 694527-83-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-((2R,3R)-3-hydroxy-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Me)-OBn
• CAS: 694527-83-8
• 化学式: C₃₄H₅₇N₃O₇
• 分子量: 619.842
• InChiKey: PCFXYZGDIHIAIR-URYLRQFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.23
• 重原子数：
  44.0
• 可旋转键数：
  21.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  134.27
• 氢给体数：
  3.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  N-Boc-O-TBS-L-allo-Thr-Gly 、 N-((2R,3R)-3-hydroxy-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Me)-OBn 在 4-二甲氨基吡啶 、 camphor-10-sulfonic acid 、 N,N'-二异丙基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以91%的产率得到N-((2R,3R)-3-[Boc-L-allo-Thr(TBS)-GlyO]-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Me)-OBn
  参考文献：
  名称：

  Structure–activity relationships of globomycin analogues as antibiotics

  摘要：

  Globomycin (1a), a signal peptidase II inhibitor, and its derivatives show potent antibacterial activity against Gram-negative bacteria. The synthesis and antimicrobial activity of novel globomycin analogues are reported. The hydroxyl group in the L-Ser residue was essential for the antimicrobial activity and the length of the alkyl side chain greatly influenced the activity. In addition, derivatives that had a modified cyclic core exhibited weak activity. One of the analogues showed a wider antimicrobial spectrum, effective against not only Gram-negative but also Gram-positive bacteria. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.10.055
• 作为产物：
  描述：

  (S)-2-tert-butoxycarbonylamino-3-methoxy-propionic acid benzyl ester 在 盐酸 、 氰基磷酸二乙酯 、 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 乙酸乙酯 为溶剂， 反应 29.3h， 生成 N-((2R,3R)-3-hydroxy-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Me)-OBn
  参考文献：
  名称：

  Structure–activity relationships of globomycin analogues as antibiotics

  摘要：

  Globomycin (1a), a signal peptidase II inhibitor, and its derivatives show potent antibacterial activity against Gram-negative bacteria. The synthesis and antimicrobial activity of novel globomycin analogues are reported. The hydroxyl group in the L-Ser residue was essential for the antimicrobial activity and the length of the alkyl side chain greatly influenced the activity. In addition, derivatives that had a modified cyclic core exhibited weak activity. One of the analogues showed a wider antimicrobial spectrum, effective against not only Gram-negative but also Gram-positive bacteria. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.10.055