(R)-2-acetoxybutanoic acid | 3347-89-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-2-acetoxybutanoic acid
• 英文别名: D-(+)-α-Acetoxy-buttersaeure；R-(+)-2-Acetoxybuttersaeure；(2R)-2-acetyloxybutanoic acid
• CAS: 3347-89-5
• 化学式: C₆H₁₀O₄
• 分子量: 146.143
• InChiKey: GELZYBXBKFHYEN-RXMQYKEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (R)-2-acetoxybutanoic acid 在 sodium hydroxide 作用下， 生成 (R)-2-羟基丁酸
  参考文献：
  名称：

  Bohlmann,F.; Grau,G., Chemische Berichte, 1965, vol. 98, p. 2608 - 2610

  摘要：

  DOI：
• 作为产物：
  描述：

  (R)-pent-1-yn-3-yl acetate 在 potassium permanganate 作用下， 以 丙酮 为溶剂， 生成 (R)-2-acetoxybutanoic acid
  参考文献：
  名称：

  Bohlmann,F.; Grau,G., Chemische Berichte, 1965, vol. 98, p. 2608 - 2610

  摘要：

  DOI：

文献信息

• Preparation and Activity of β-Substituted Acetylcholine Iodides
  作者：George H. Cocolas、Ellen C. Robinson、William L. Dewey、Theodore C. Spaulding

  DOI：10.1002/jps.2600601144

  日期：1971.11

  enantiometers of (—)- and (+)-acetyl β-ethylcholine iodide were prepared following the resolution of 1-dimethylamino-2-butanol from (+)-tartaric acid and (+)-bromocamphor-sulfonic acid for the (—)- and (+)-isomers, respectively. The absolute configuration of the (—)-enantiomer was determined by the synthesis of (—)-acetyl β-ethylcholine iodide from R(—)-2-hydroxybutyric acid. The optically active acetyl β-phenylcholine

  （-）-和（+）-乙酰基β-乙基胆碱碘化物的对映异构体是根据（-）从（+）-酒石酸和（+）-溴樟脑-磺酸中分离出1-二甲氨基-2-丁醇而制得的。 ）和（+）异构体。（-）-对映异构体的绝对构型通过由R（-）-2-羟基丁酸合成（-）-乙酰基β-乙基胆碱碘化物来确定。由旋光的扁桃酸制备旋光的乙酰基β-苯基胆碱碘化物。这些对映异构体表明，R（-）异构体对乙酰胆碱酯酶受体具有更高的亲和力，而S（+）异构体是对豚鼠回肠的更强效激动剂。
• [EN] PROCESSES FOR PREPARATION OF IDELALISIB AND INTERMEDIATES THEREOF<br/>[FR] PROCÉDÉS DE PRÉPARATION D'IDÉLALISIB ET DE SES INTERMÉDIAIRES
  申请人：DR REDDY’S LABORATORIES LTD

  公开号：WO2016108206A3

  公开（公告）日：2016-08-18
• New diterpene pyrone-type compounds, metarhizins A and B, isolated from entomopathogenic fungus, Metarhizium flavoviride and their inhibitory effects on cellular proliferation
  作者：Haruhisa Kikuchi、Tomoko Hoshi、Minoru Kitayama、Mizuki Sekiya、Yasuhiro Katou、Kazunori Ueda、Yuzuru Kubohara、Hiroki Sato、Mitsuaki Shimazu、Shoichiro Kurata、Yoshiteru Oshima

  DOI：10.1016/j.tet.2008.11.014

  日期：2009.1

  To date, entomopathogenic fungi have not been extensively examined by natural product chemists. In this study, we isolated novel pyrone diterpene-type compounds, metarhizins A (1) and B (2), from methanol extracts of entomopathogenic fungus, Metarhizium flavoviride. They showed potent and selective antiproliferative activity against both insect and human cancer cell lines. These results indicate that metarhizins A (1) and B (2) can be used as novel lead compounds for anti-cancer agents and probes for cell cycle regulation. To further investigate the structural requirements for this inhibitory activity, we synthesized many metarhizin derivatives and evaluated their antiproliferative activities. (C) 2008 Elsevier Ltd. All rights reserved.
• EP0168480A4
  申请人：——

  公开号：EP0168480A4

  公开（公告）日：1987-10-08
• PROCESS FOR PREPARING OPTICALLY-ACTIVE 4-AMINO-3-HYDROXYBUTYRIC ACID
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：EP0168480A1

  公开（公告）日：1986-01-22