(4-Formyltetrahydropyran-4-yl)carbamic acid tert-butyl ester | 885498-49-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: (4-Formyltetrahydropyran-4-yl)carbamic acid tert-butyl ester
• 英文别名: tert-butyl N-(4-formyloxan-4-yl)carbamate
• CAS: 885498-49-7
• 化学式: C₁₁H₁₉NO₄
• 分子量: 229.27
• InChiKey: PURZULSTVLZMPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (4-Formyltetrahydropyran-4-yl)carbamic acid tert-butyl ester 、 4-溴苯胺 、 溶剂黄146 、 氰基硼氢化钠 在 氮 、 水 、 氯化钠 、 magnesium sulfate 、 silica gel 、 ethyl acetate n-hexane 作用下， 以 乙酸乙酯 为溶剂， 反应 2.0h， 以to isolate the desired product as 3.1 g of white solid foam的产率得到{4-[(4-Bromo-phenylamino)-methyl]-tetrahydro-pyran-4-yl}-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Modulators of G protein-coupled receptor 88

  摘要：

  本公开涉及可以调节G蛋白偶联受体88的化合物，包含这种化合物的组合物以及调节G蛋白偶联受体88的方法。

  公开号：

  US08426414B2
• 作为产物：
  描述：

  二甲基亚砜 、 草酰氯 、 N-[4-(羟甲基)氧杂-4-基]氨基甲酸叔丁酯 、 三乙胺 在 氮 、 氯化钠 、 magnesium sulfate 作用下， 以 二氯甲烷 为溶剂， 反应 0.8h， 以to afford 4.48 g of clear yellow viscous liquid which的产率得到(4-Formyltetrahydropyran-4-yl)carbamic acid tert-butyl ester
  参考文献：
  名称：

  Modulators of G protein-coupled receptor 88

  摘要：

  本公开涉及可以调节G蛋白偶联受体88的化合物，包含这种化合物的组合物以及调节G蛋白偶联受体88的方法。

  公开号：

  US08426414B2

文献信息

• [EN] MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88<br/>[FR] MODULATEURS DE RÉCEPTEUR 88 COUPLÉ AUX PROTÉINES G
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2011044212A1

  公开（公告）日：2011-04-14

  The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.

  本公开涉及的是能够调节G蛋白偶联受体88的化合物，包含这种化合物的组合物，以及调节G蛋白偶联受体88的方法。
• 3-Carbamoyl-2-Pyridone Derivative
  申请人：Ishizuka Natsuki

  公开号：US20080103139A1

  公开（公告）日：2008-05-01

  The present invention provides compounds having an agonistic activity to the cannabinoid receptor, which is represented by the formula (I): wherein R 1 is optionally substituted C1-C8 alkyl and the like; R 2 is C1-C6 alkyl; R 3 is C1-C6 alkyl and the like; or R 2 and R 3 taken together with may form an optionally substituted 5 to 10 membered non-aromatic carbon ring; R 4 is hydrogen and the like; G is a group selected from the groups shown by the formula an the like: wherein R 5 is hydrogen and the like; X 1 is a single bond and the like; X 2 is optionally substituted C1-C8 alkylene that may be replaced by one or two groups of —O—, or —N(R 6 )—, wherein R 6 is hydrogen and the like, and the like; X 3 is a single bond and the like; a pharmaceutically acceptable salt or a solvate thereof, and pharmaceutical compositions, atopic dermatitis treating agents, and anti-pruritus agents, especially anti-pruritus agents for oral used and for external application, which each contains the said compound as an active ingredient.

  本发明提供了具有激动大麻素受体的作用的化合物，其由式（I）表示：其中，R1是可选取的取代的C1-C8烷基等；R2是C1-C6烷基；R3是C1-C6烷基等；或R2和R3共同形成可选取代的5至10个成员的非芳香碳环；R4是氢等；G是由式等所示的基团中选取的基团：其中，R5是氢等；X1是单键等；X2是可选取代的C1-C8烷基，可以被一或两个-O-或-N（R6）-的基团替代，其中R6是氢等；X3是单键等；其药学上可接受的盐或其溶剂，以及制药组合物、治疗特应性皮炎的制剂和抗瘙痒剂，特别是口服和外用的抗瘙痒剂，每种制剂均以所述化合物为活性成分。
• 3-carbamoyl-2-pyridone derivatives
  申请人：Shionogi & Co., Ltd.

  公开号：US08178681B2

  公开（公告）日：2012-05-15

  The present invention provides compounds having an agonistic activity to the cannabinoid receptor, which is represented by the formula (I): wherein R1 is optionally substituted C1-C8 alkyl and the like; R2 is C1-C6 alkyl; R3 is C1-C6 alkyl and the like; or R2 and R3 taken together with may form an optionally substituted 5 to 10 membered non-aromatic carbon ring; R4 is hydrogen and the like; G is a group selected from the groups shown by the formula an the like: wherein R5 is hydrogen and the like; X1 is a single bond and the like; X2 is optionally substituted C1-C8 alkylene that may be replaced by one or two groups of —O—, or —N(R6)—, wherein R6 is hydrogen and the like, and the like; X3 is a single bond and the like; a pharmaceutically acceptable salt or a solvate thereof, and pharmaceutical compositions, atopic dermatitis treating agents, and anti-pruritus agents, especially anti-pruritus agents for oral used and for external application, which each contains the said compound as an active ingredient.

  本发明提供了具有类脑受体激动活性的化合物，其由式（I）所表示：其中R1是可选取代的C1-C8烷基等；R2是C1-C6烷基；R3是C1-C6烷基等；或R2和R3结合在一起可以形成一个可选取代的5到10个成员的非芳香碳环；R4是氢等；G是通过式等所示的基团中选择的基团：其中R5是氢等；X1是单键等；X2是可选取代的C1-C8烷基，可以被一个或两个-O-或-N（R6）-等基团所代替，其中R6是氢等等；X3是单键等；以及含有所述化合物作为活性成分的药物学上可接受的盐或溶剂和制药组合物，特别是用于口服和外用的抗瘙痒剂和特应性皮炎治疗剂。
• 3-CARBAMOYL-2-PYRIDONE DERIVATIVES
  申请人：ISHIZUKA Natsuki

  公开号：US20120208813A1

  公开（公告）日：2012-08-16

  The present invention provides compounds having an agonistic activity to the cannabinoid receptor, which is represented by the formula (I): wherein R 1 , R 2 , R 3 , R 4 , and G are defined as herein, a pharmaceutically acceptable salt or a solvate thereof, and pharmaceutical compositions, atopic dermatitis treating agents, and anti-pruritus agents, especially anti-pruritus agents for oral used and for external application, which each contains the said compound as an active ingredient.

  本发明提供了具有激动大麻素受体的活性的化合物，该受体由公式（I）表示：其中R1、R2、R3、R4和G如本文所定义，其药学上可接受的盐或溶剂，以及制备该化合物为活性成分的药物组合物、治疗特应性皮炎的药剂和抗瘙痒剂，尤其是用于口服和外用的抗瘙痒剂。
• Modulators of G Protein-Coupled Receptor 88
  申请人：Bi Yingzhi

  公开号：US20110251204A1

  公开（公告）日：2011-10-13

  The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.

  本公开涉及一般性的化合物，可以调节G-蛋白偶联受体88，包括这些化合物的组合物和调节G-蛋白偶联受体88的方法。