6-Fluoro-3-[2-(pyridin-4-yl)ethenyl]-1H-indole | 177181-27-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 6-Fluoro-3-[2-(pyridin-4-yl)ethenyl]-1H-indole
• 英文别名: 6-fluoro-3-(2-pyridin-4-ylethenyl)-1H-indole
• CAS: 177181-27-0
• 化学式: C₁₅H₁₁FN₂
• 分子量: 238.26
• InChiKey: UJTBWNKRXRHIGU-UHFFFAOYSA-N

物化性质

• 沸点：
  438.9±35.0 °C(Predicted)
• 密度：
  1.305±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• METHODS AND COMPOSITIONS TO STABILIZE DIFFERENT STEM CELL STATES
  申请人：UNIVERSITY OF WASHINGTON - CENTER COMMERCIALIZATION

  公开号：US20170121678A1

  公开（公告）日：2017-05-04

  Provided herein are methods and compositions for maintaining human stem cells in either a nave state or a primed state, inducing, promoting, inhibiting, or controlling the transition from one state to another, and detecting the state of a stem cell. Also disclosed are compositions comprising substantially homogenous populations of primed state or nave state stem cells.
• [EN] TRYPTOPHAN CATABOLISM IN CANCER TREATMENT AND DIAGNOSIS<br/>[FR] CATABOLISME DU TRYPTOPHANE DANS LE TRAITEMENT ET LE DIAGNOSTIC DU CANCER
  申请人：LUDWIG INST FOR CANCER RES LTD

  公开号：WO2010008427A1

  公开（公告）日：2010-01-21

  The unexpected expression of tryptophan 2,3-dioxygenase (TD02)in cancer cells and tumors has been established. Methods for diagnosing cancer based on the expression of TD02 are provided, as are methods for treating cancer and inhibiting the growth of cancer cells by inhibiting TD02, as well as pharmaceutical compositions.