4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-[(2-fluoroethyl)amino]-2-oxoethyl]-1-naphthalenecarboxamide | 1093861-15-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-[(2-fluoroethyl)amino]-2-oxoethyl]-1-naphthalenecarboxamide
• 英文别名: 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-N-[2-(2-fluoroethylamino)-2-oxoethyl]naphthalene-1-carboxamide
• CAS: 1093861-15-4
• 化学式: C₂₅H₁₉Cl₂F₄N₃O₃
• 分子量: 556.344
• InChiKey: HOKGODVBSJYIQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  79.8
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• NAPHTHALENE ISOXAZOLINE INVERTEBRATE PEST CONTROL AGENTS
  申请人：Lahm George Philip

  公开号：US20100254959A1

  公开（公告）日：2010-10-07

  Disclosed are compounds of Formula 1, wherein R 1 is halogen, C 1 -C 2 haloalkyl or C 1 -C 2 haloalkoxy; R 2 is H, halogen or cyano; R 3 is H, halogen or CF 3 ; R 4 is H, C 2 -C 7 alkylcarbonyl or C 2 -C 7 alkoxycarbonyl; and R 5 is C 1 -C 6 alkyl or C 1 -C 6 haloalkyl, each substituted with one substituent independently selected from hydroxy, C 1 -C 6 alkoxy, C 1 -C 6 alkylthio, C 1 -C 6 alkylsulfinyl, C 1 -C 6 alkylsulfonyl, C 2 -C 7 alkylaminocarbonyl, C 3 -C 9 dialkylaminocarbonyl, C 2 -C 7 haloalkylaminocarbonyl and C 3 -C 9 halodialkylaminocarbonyl. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

  本文披露了Formula 1的化合物，其中R1是卤素，C1-C2卤代烷基或C1-C2卤代氧烷基；R2是H、卤素或氰基；R3是H、卤素或三氟甲基；R4是H、C2-C7烷基羰基或C2-C7烷氧羰基；R5是C1-C6烷基或C1-C6卤代烷基，每个都被一个取自羟基、C1-C6烷氧基、C1-C6烷基硫醚、C1-C6烷基亚砜基、C1-C6烷基砜基、C2-C7烷基氨基羰基、C3-C9二烷基氨基羰基、C2-C7卤代烷基氨基羰基和C3-C9卤代二烷基氨基羰基的取代基独立取代。还披露了含有Formula 1化合物的组合物以及用于控制无脊椎动物害虫的方法，包括将无脊椎动物害虫或其环境与本发明的化合物或组合物的生物有效量接触。
• Naphthalene Isoxazoline Invertebrate Pest Control Agents
  申请人：E. I. Du Pont de Nemours and Company

  公开号：US20130217736A1

  公开（公告）日：2013-08-22

  Disclosed are compounds of Formula 1, wherein R 1 is halogen, C 1 -C 2 haloalkyl or C 1 -C 2 haloalkoxy; R 2 is H, halogen or cyano; R 3 is H, halogen or CF 3 ; R 4 is H, C 2 -C 7 alkylcarbonyl or C 2 -C 7 alkoxycarbonyl; and R 5 is C 1 -C 6 alkyl or C 1 -C 6 haloalkyl, each substituted with one substituent independently selected from hydroxy, C 1 -C 6 alkoxy, C 1 -C 6 alkylthio, C 1 -C 6 alkylsulfinyl, C 1 -C 6 alkylsulfonyl, C 2 -C 7 alkylaminocarbonyl, C 3 -C 9 dialkylaminocarbonyl, C 2 -C 7 haloalkylaminocarbonyl and C 3 -C 9 halodialkylaminocarbonyl. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

  本发明涉及一种化合物，其化学式为1，其中R1为卤素，C1-C2卤代烷基或C1-C2卤代氧烷基；R2为H，卤素或氰基；R3为H，卤素或CF3；R4为H，C2-C7烷基羰基或C2-C7烷氧羰基；R5为C1-C6烷基或C1-C6卤代烷基，每个烷基上都独立地取代一个取代基，所述取代基选择自羟基、C1-C6烷氧基、C1-C6烷基硫醚基、C1-C6烷基亚砜基、C1-C6烷基磺酰基、C2-C7烷基氨基羰基、C3-C9二烷基氨基羰基、C2-C7卤代烷基氨基羰基和C3-C9卤代二烷基氨基羰基。本发明还涉及含有化合物1的组合物以及用化合物或本发明的组合物的生物有效量与无脊椎动物害虫或其环境接触以控制无脊椎动物害虫的方法。
• NAPTHALENE ISOXAZOLINE INVERTEBRATE PEST CONTROL AGENTS
  申请人：E. I. du Pont de Nemours and Company

  公开号：EP3222618B1

  公开（公告）日：2020-09-09
• EXTENDED RELEASE INJECTABLE FORMULATIONS COMPRISING AN ISOXAZOLINE ACTIVE AGENT, METHODS AND USES THEREOF
  申请人：MERIAL INC.

  公开号：US20170020848A1

  公开（公告）日：2017-01-26

  This invention relates to extended release injectable formulations for combating parasites in animals, comprising at least one isoxazoline active agent, a pharmaceutically acceptable polymer, and a solvent. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the extended release injectable formulations of the invention to the animal in need thereof.
• US8410153B2
  申请人：——

  公开号：US8410153B2

  公开（公告）日：2013-04-02