5,7-Diallylchrysin | 55390-56-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 5,7-Diallylchrysin
• 英文别名: 5,7-bis-allyloxy-2-phenyl-chromen-4-one；5,7-Diallyloxy-2-phenyl benzopyran-4H-one；2-phenyl-5,7-bis(prop-2-enoxy)chromen-4-one
• CAS: 55390-56-2
• 化学式: C₂₁H₁₈O₄
• 分子量: 334.372
• InChiKey: OGFABCCPYSIRCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] ANTI-ULCER ACTIVITY OF FLAVONE ANALOGS<br/>[FR] ACTIVITÉ ANTI-ULCÈRE D'ANALOGUES DE LA FLAVONE
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2009110008A1

  公开（公告）日：2009-09-11

  The present invention relates to the use of a compound of general formula (1), useful for anti- ulcer activity. The compounds comprising substituted chrysin or substituted 7-hydroxy flavone analogs of the formula (1) wherein R' is selected from the group consisting of alkyl, alkenyl, alkoyl,benzoyl, hydrogen, carboxymethyl, acetamjde and R" is selected from the group consisting of H, OH, alkoxy, acetoxy and propenyl. More particularly, the present invention provides the use of analogs of 7-hydroxy flavone, to provide anti-ulcer against aspirin induced ulceration, pylorus ligation induced ulceration, ethanol induced ulceration and stress induced ulceration at a dose ranging between.1 -25mg/kg body weight.