N-(3,5-di-tert-butylphenyl)-4-methylimidazole | 924709-42-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(3,5-di-tert-butylphenyl)-4-methylimidazole
• 英文别名: 1-(3,5-Ditert-butylphenyl)-4-methylimidazole
• CAS: 924709-42-2
• 化学式: C₁₈H₂₆N₂
• 分子量: 270.418
• InChiKey: AQTJHRQGZMTNDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Activation of the Renin-Angiotensin System (RAS) and Sudden Cardiac Death
  申请人：Dudley Samuel

  公开号：US20110207741A1

  公开（公告）日：2011-08-25

  Provided herein are methods of treating a medical condition in which RAS activation is increased. The method comprises the step of administering to a subject a c-Src inhibitor in an amount effective to treat the medical condition. The invention also provides a method of treating or preventing a cardiac arrhythmia. The method comprises the step of administering to the subject a c-Src inhibitor in an amount effective to treat or prevent the cardiac arrhythmia. The invention additionally provides a method of delaying the onset of sudden cardiac death. The method comprises the step of administering to the subject a c-Src inhibitor in an amount effective to delay the onset of SCD. Methods of augmenting gap junction function and methods of increasing Connexin 43 levels in a subject in need thereof are further provided.