4-(4-phenyl-1H-imidazol-1-yl)piperidinedihydrochloride | 1205637-77-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(4-phenyl-1H-imidazol-1-yl)piperidinedihydrochloride
• 英文别名: 4-(4-phenylimidazol-1-yl)piperidine;dihydrochloride
• CAS: 1205637-77-9
• 化学式: C14H19Cl2N3
• 分子量: 300.2
• InChiKey: MAJIKTTZFDFVSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.32
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  29.8
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• IMIDAZOLE DERIVATIVE
  申请人：DAINIPPON SUMITOMO PHARMA CO., LTD.

  公开号：US20150259344A1

  公开（公告）日：2015-09-17

  Provided is a therapeutic agent for diseases associated with a cholinergic property of the central nervous system (CNS) and/or the peripheral nervous system (PNS), diseases associated with the contraction of smooth muscle, incretion disease, diseases associated with neuronal degeneration and the like, said therapeutic agent comprising a compound represented by Formula (I): [wherein X—Y—Z represents N—CO—NR 4A R 4B or the like; R 1 represents a phenyl group or the like; R 2A and R 2B may be the same as or different from each other and independently represent a hydrogen atom or the like; R 3A to R 3D and R 6 may be the same as or different from one another and independently represent a hydrogen atom or the like; R 4A and R 4B may be the same as or different from each other and independently represent an aryl group or the like; and n represents 1 or 2] or a pharmaceutically acceptable salt thereof and having a potent activity of regulating an α7 nicotinic acetylcholine receptor (an α7 nAChR).

  提供一种治疗剂，用于与中枢神经系统（CNS）和/或外周神经系统（PNS）的胆碱能性质相关的疾病、与平滑肌收缩相关的疾病、内分泌疾病、与神经退行性疾病等相关的疾病，所述治疗剂包括以下式（I）所表示的化合物：[其中X—Y—Z表示N—CO—NR4AR4B或类似物；R1表示苯基或类似物；R2A和R2B可以相同或不同，独立地表示氢原子或类似物；R3A到R3D和R6可以相同或不同，独立地表示氢原子或类似物；R4A和R4B可以相同或不同，独立地表示芳基或类似物；n表示1或2]或其药学上可接受的盐，具有调节α7尼古丁乙酰胆碱受体（α7 nAChR）的强效活性。