4-[(乙氧羰基)氧基]苯甲酸 | 15552-32-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-[(乙氧羰基)氧基]苯甲酸
• 中文别名: 4-乙氧基碳氧基苯甲酸
• 英文名称: 4-Ethoxycarbonyloxybenzoic acid
• 英文别名: Ethyl-p-benzoesaeurecarbonat；p-Aethoxycarbonyloxy-benzoesaeure；5-Aethoxycarbonyloxybenzoesaeure；4-Aethoxycarbonyloxy-benzoesaeure；(4-Oxy-benzoesaeure)-O-carbonsaeureaethylester；Aethyl-(4-carboxy-phenyl)-carbonat；4-(Carbaethoxy-oxy)-benzoesaeure；Carbaethoxy-p-oxy-benzoesaeure；p-carbethoxy-oxybenzoic acid；4-[(Ethoxycarbonyl)oxy]benzoic acid
• CAS: 15552-32-6
• 化学式: C₁₀H₁₀O₅
• mdl: MFCD00059646
• 分子量: 210.186
• InChiKey: UXVMHSYMNTYLPO-UHFFFAOYSA-N

物化性质

• 熔点：
  154-156 °C
• 沸点：
  360.8±34.0 °C(Predicted)
• 密度：
  1.293±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2918990090

反应信息

• 作为反应物：
  描述：

  4-[(乙氧羰基)氧基]苯甲酸 在 硝酸 作用下， 生成 carbonic acid ethyl ester-(2,4-dinitro-phenyl ester)
  参考文献：
  名称：

  King; Murch, Journal of the Chemical Society, 1925, vol. 127, p. 2649

  摘要：

  DOI：
• 作为产物：
  描述：

  氟甲酸乙酯 、 alkaline earth salt of/the/ methylsulfuric acid 生成 4-[(乙氧羰基)氧基]苯甲酸
  参考文献：
  名称：

  Emeleus; Wood, Journal of the Chemical Society, 1948, p. 2186

  摘要：

  DOI：

文献信息

• [EN] 1- (2H-PYRAZOL -3-YL) -3YL) {4-`1- (BENZOYL) -PIPERIDIN-4-YLMETHYL!-PHENYL}-UREA DERIVATIVES AND RELATED COMPOUNDS AS INHBITORS OF P38 KINASE AND/OR TNF INHIBITORS FOR THE TREATMENT OF IMFLAMMATIONS<br/>[FR] DERIVES DE 1-(2H-PYRAZOL-3-YL)-3-{4-`1-(BENZOYL)-PIPERIDIN-4-YLMETHYL!-PHENYL}-UREE ET COMPOSES ASSOCIES UTILISES COMME INHIBITEURS DE LA KINASE P38 ET/OU COMME INHIBITEURS DU FACTEUR DE NECROSE TUMORALE (TNF) DANS LE TRAITEMENT DES INFLAMMATIONS
  申请人：AVENTIS PHARMA INC

  公开号：WO2004100946A1

  公开（公告）日：2004-11-25

  The present invention provides compounds of Formula (I) Wherein ( ) is an optional ethylene bridge; R1 is alkyl, cycloalkyl, aryl or aryl substituted with one or more substituents selected from alkyl, alkoxy and amino, or R1 is pyridyl or pyridyl substituted with one or more substituents selected from alkyl, alkoxy and amino; R2 is optionally substituted alkyl, alkoxyalkyl, optionally substituted cycloalkylalkyl, arylalkyl, or R2 is arylalkyl substituted with one or more substituents selected from alkyl, alkoxy; X is -C(O)-, -C(O)-CH2-, -S(O)2-, or NH-C(O)- ; and A is optionally substituted alkyl or other substituents as defined in claim 1. Pharmaceutical compositions comprising such compounds, their preparation, and their pharmaceutical use in the treatment of disease states capable of being modulated by the inhibition of p38 kinase and/or tumor necrosis factor (TNF), such as asthma or joint inflammation.

  本发明提供了Formula (I)的化合物，其中( )是可选的乙烯桥；R1是烷基、环烷基、芳基或芳基，其上取代基可为烷基、烷氧基和氨基中的一种或多种，或者R1是吡啶基或吡啶基，其上取代基可为烷基、烷氧基和氨基中的一种或多种；R2是可选取代的烷基、烷氧基烷基、可选取代的环烷基烷基、芳基烷基，或者R2是芳基烷基，其上取代基可为烷基、烷氧基中的一种或多种；X是-C(O)-、-C(O)-CH2-、-S(O)2-或NH-C(O)-；A是可选取代的烷基或其他在权利要求1中定义的取代基。包括这些化合物的药物组合物、其制备以及在治疗能够通过抑制p38激酶和/或肿瘤坏死因子(TNF)调节的疾病状态中的药用，如哮喘或关节炎。
• Pyrazoles as inhibitors of tumor necrosis factor
  申请人：Borcherding R. David

  公开号：US20060063796A1

  公开（公告）日：2006-03-23

  The present invention provides compounds of Formula (I) and ester prodrugs, pharmaceutically acceptable salts or solvates of such compounds; or ester prodrugs of such salts or solvates; pharmaceutical compositions comprising such compounds, their preparation, and their pharmaceutical use in the treatment of disease states capable of being modulated by the inhibition of p38 kinase and/or tumor necrosis factor (TNF).

  本发明提供了式（I）的化合物和酯前药、这些化合物的药学上可接受的盐或溶剂；或这些盐或溶剂的酯前药；包括这些化合物的制药组合物，其制备以及它们在治疗能够通过抑制p38激酶和/或肿瘤坏死因子（TNF）调节的疾病状态中的药物应用。
• Detergent composition and method for producing it
  申请人：UNILEVER PLC

  公开号：EP0030089A1

  公开（公告）日：1981-06-10

  A particulate alkaline detergent composition is disclosed which is suitable for washing fabrics and exhibiting good detergency, stability and bleaching while the level of inorganic material deposited on the fabrics is at an acceptably low level. The composition comprises a synthetic detergent active, a mixture of tri-polyphosphate and orthophosphate in the ratio of 20:1 to 3:1 and a mixture of a peroxygen bleach such as perborate and a bleach activator such as tet- raacetylethylenediamine. The phosphates constitute from 10 to 40% of the composition while the bleach system constitutes from 5 to 30%. The amount of pyrophosphate, if any, should be kept below 5% Soap may be added to the composition. The compositions may be prepared by mixing the bleach system and optionally the alkali metal phosphate with a spray dried powder containing the remaining constituents.

  本发明公开了一种微粒碱性洗涤剂组合物，该组合物适用于洗涤织物，具有良好的去污力、稳定性和漂白性，同时织物上沉积的无机物含量低得可以接受。该组合物包括一种合成洗涤剂活性物、一种比例为 20:1 至 3:1 的三聚磷酸酯和正磷酸酯的混合物，以及一种过氧漂白剂（如过硼酸盐）和一种漂白活化剂（如四乙酰乙二胺）的混合物。磷酸盐占组合物的 10%至 40%，而漂白体系占 5%至 30%。焦磷酸盐的用量（如果有的话）应保持在 5%以下，可在组合物中添加肥皂。可将漂白剂和碱金属磷酸盐与含有其余成分的喷雾干燥粉末混合，制备组合物。
• Detergent compositions
  申请人：UNILEVER PLC

  公开号：EP0056723A1

  公开（公告）日：1982-07-28

  A particulate alkaline detergent with unexpectantly good bleaching performance and with reduced phosphorus content contains 5-40% detergent active, 12.5-25% tripolyphosphate, 7.0-36% aluminosilicate builder such as zeolite, 5-30% peroxybleach such as sodium perborate and 0.1 to 15% activator such as TAED, the perborate to TAED ratio being between 2:1 and 15:1. The detergent active may be anionic material or a mixture of an anionic material and a minor amount of nonionic material. The compositions are particularly suitable for containing fluorescers and show surprisingly improved bleaching performance as water hardness increases.

  一种漂白性能出乎意料地好并能降低磷含量的微粒碱性洗涤剂含有 5-40%的洗涤活性剂、12.5-25%的三聚磷酸钠、7.0-36%的铝硅酸盐掺合物（如沸石）、5-30%的过氧漂白剂（如过硼酸钠）和 0.1-15%的活化剂（如 TAED），过硼酸钠和 TAED 的比例在 2:1 和 15:1 之间。活性洗涤剂可以是阴离子材料，也可以是阴离子材料和少量非离子材料的混合物。这种组合物特别适合含有荧光剂，而且随着水硬度的增加，漂白性能也会惊人地提高。
• Detergent additives and detergent compositions containing them
  申请人：UNILEVER PLC

  公开号：EP0070190A1

  公开（公告）日：1983-01-19

  A builder system for detergent compositions comprises 25 to 97% by weight of an aluminosilicate cation-exchange material such as Zeolite A and 3 to 75% by weight, in total, of an organic precipitant builder having a polyvalent anion, for example, an alkyl or alkenyl malonate or succinate, and an organic sequestrant such as a nitrilotriacetate. The ratio of precipitant to sequestrant is 10:1 to 1:10. The builder mix is advantageously used in detergent compositions containing less than 10% inorganic phosphate, and gives good results in zero-phosphate compositions.

  一种用于洗涤剂组合物的增效剂体系包括 25-97%（重量）的硅酸铝阳离子交换材料（如沸石 A）和 3-75%（重量）的具有多价阴离子的有机沉淀剂增效剂（如烷基或烯基丙二酸酯或琥珀酸酯）以及有机螯合剂（如氮基三乙酸酯）。沉淀剂和螯合剂的比例为 10:1 至 1:10。这种增效剂混合物适用于无机磷酸盐含量低于 10%的洗涤剂组合物，在零磷酸盐组合物中也有很好的效果。

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