4-(2-{1-acetyl-2-[4-(3-bromophenyl)-3-hydroxybutyl]hydrazino}ethyl)benzoic acid | 841234-50-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 4-(2-{1-acetyl-2-[4-(3-bromophenyl)-3-hydroxybutyl]hydrazino}ethyl)benzoic acid
• 英文别名: 4-[2-[Acetyl-[[4-(3-bromophenyl)-3-hydroxybutyl]amino]amino]ethyl]benzoic acid
• CAS: 841234-50-2
• 化学式: C₂₁H₂₅BrN₂O₄
• 分子量: 449.344
• InChiKey: YKVDIXCCHDSJMS-UHFFFAOYSA-N

物化性质

• 沸点：
  623.6±65.0 °C(Predicted)
• 密度：
  1.396±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  89.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Hydrazide derivatives as prostaglandin receptors modulators
  申请人：Araldi Luca Gian

  公开号：US20070185191A1

  公开（公告）日：2007-08-09

  The present invention relates to hydrazide derivatives of Formula I notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such hydrazide derivatives. Said hydrazide derivatives are useful in the treatment of preterm labor, dysmenorrhea, fertility disorders, asthma, hypertension, undesired blood clotting, preelampsia, eclampsia, an eosinophil disorder, undesired bone loss, renal dysfunction, an immune deficiency disorder, ichthyosis, elevated intraocular pressure, infertility, sexual dysfunction, gastric ulcers and inflammatory disorders.

  本发明涉及公式I的肼酰肼衍生物，特别是用作药物活性化合物，以及包含这种肼酰肼衍生物的制药配方。所述肼酰肼衍生物在早产、痛经、生育障碍、哮喘、高血压、不良血液凝固、先兆子痫、子痫前期、嗜酸性细胞异常增多症、不良骨质流失、肾功能障碍、免疫缺陷病、鱼鳞病、眼内压增高、不孕不育、性功能障碍、胃溃疡和炎症性疾病的治疗中有用。
• HYDRAZIDE DERIVATIVES AS PROSTAGLANDIN RECEPTORS MODULATORS
  申请人：Applied Research Systems ARS Holding N.V.

  公开号：EP1654219A2

  公开（公告）日：2006-05-10
• US7465755B2
  申请人：——

  公开号：US7465755B2

  公开（公告）日：2008-12-16
• [EN] HYDRAZIDE DERIVATIVES AS PROSTAGLANDIN RECEPTORS MODULATORS<br/>[FR] DERIVES D'HYDRAZIDES CONSTITUANT DES MODULATEURS DES RECEPTEURS DE LA PROSTAGLANDINE
  申请人：APPLIED RESEARCH SYSTEMS

  公开号：WO2005012232A2

  公开（公告）日：2005-02-10

  The present invention relates to hydrazide derivatives of Formula (I) notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such hydrazide derivatives. Said hydrazide derivatives are useful in the treatment of preterm labor, dysmenorrhea, fertility disorders, asthma, hypertension, undesired blood clotting, preelampsia, eclampsia, an eosinophil disorder, undesired bone loss, renal dysfunction, an immune deficiency disorder, ichthyosis, elevated intraocular pressure, infertility, sexual dysfunction, gastric ulcers and inflammatory disorders.