monopropyl methylmalonate | 1043924-57-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: monopropyl methylmalonate
• 英文别名: 2-Methyl-3-oxo-3-propoxypropanoic acid
• CAS: 1043924-57-7
• 化学式: C₇H₁₂O₄
• 分子量: 160.17
• InChiKey: DGEOCCNLLMOSEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  methylpropylmalonic ester 在 氢氧化钾 、 水 、 盐酸 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以97%的产率得到monopropyl methylmalonate
  参考文献：
  名称：

  WO2008/150487

  摘要：

  公开号：

文献信息

• Highly efficient selective monohydrolysis of dialkyl malonates and their derivatives
  作者：Satomi Niwayama、Hanjoung Cho、Chunlei Lin

  DOI：10.1016/j.tetlet.2008.05.007

  日期：2008.7

  The highly efficient selective monohydrolysis of symmetric diesters has been applied to monohydrolysis of several dialkyl malonates and their derivatives. The best conditions apply 0.8-1.2 equiv of aqueous KOH with a co-solvent, THF or acetonitrile, at 0 degrees C. The procedure is highly practical, yielding the corresponding half-esters in high yields in a straightforward manner, without inducing decarboxylation. It was found that the selectivity tends to become higher with increased hydrophobicity. (c) 2008 Elsevier Ltd. All rights reserved.
• Synthesis of half esters
  申请人：Niwayama Satomi

  公开号：US20090023945A1

  公开（公告）日：2009-01-22

  A method for hydrolyzing an ester is provided. In accordance with the method, a compound A is provided which has first and second ester moieties. The compound is reacted in a liquid medium with a base having the formula M a X b , such that the first ester moiety is converted to a carboxyl moiety and the second ester moiety remains, wherein the ratio [X k− ]:[A] in the liquid medium is no greater than 1.6, and wherein k>0.
• SYNTHESIS OF HALF ESTERS
  申请人：Niwayama Satomi

  公开号：US20130150613A1

  公开（公告）日：2013-06-13

  A method for hydrolyzing an ester is provided. In accordance with the method, a compound A is provided which has first and second ester moieties. The compound is reacted in a liquid medium with a base having the formula M a X b , such that the first ester moiety is converted to a carboxyl moiety and the second ester moiety remains, wherein the ratio [X k− ]:[A] in the liquid medium is no greater than 1.6, and wherein k>0.
• US8338635B2
  申请人：——

  公开号：US8338635B2

  公开（公告）日：2012-12-25
• [EN] SYNTHESIS OF HALF ESTERS<br/>[FR] SYNTHÈSE D'HÉMIESTERS
  申请人：UNIV TEXAS TECH

  公开号：WO2008150487A2

  公开（公告）日：2008-12-11

  [EN] A method for hydrolyzing an ester is provided. In accordance with the method, a compound A is provided which has first and second ester moieties. The compound is reacted in a liquid medium with a base having the formula MaXb,such that the first ester moiety is converted to a carboxyl moiety and the second ester moiety remains, wherein the ratio [Xk-]:[A] in the liquid medium is no greater than 1.6, and wherein k > 0.
  [FR] L'invention concerne un procédé pour hydrolyser un ester. Selon le procédé, on fournit un composé A qui a des première et seconde fractions d'ester. Le composé est amené à réagir dans un milieu liquide avec une base ayant pour formule MaXb, de sorte que la première fraction d'ester est convertie en une fraction carboxyle et la deuxième fraction d'ester reste, le rapport [Xk-] : [A] dans le milieu liquide n'étant pas supérieur à 1,6, et dans lequel k > 0.