2-(difluoromethyl)-5-[(2-methylpropanoylamino)methyl]-N-[4-methyl-5-(p-tolyl)-1H-imidazol-2-yl]pyridine-3-carboxamide | 1415089-36-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(difluoromethyl)-5-[(2-methylpropanoylamino)methyl]-N-[4-methyl-5-(p-tolyl)-1H-imidazol-2-yl]pyridine-3-carboxamide
• 英文别名: 2-(difluoromethyl)-N-[5-methyl-4-(4-methylphenyl)-1H-imidazol-2-yl]-5-[(2-methylpropanoylamino)methyl]pyridine-3-carboxamide
• CAS: 1415089-36-9
• 化学式: C₂₃H₂₅F₂N₅O₂
• 分子量: 441.481
• InChiKey: XUGIKVVYUVCHIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  99.8
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Novel Imidazole Derivatives Useful for the Treatment of Arthritis
  申请人：Hughes Norman Earle

  公开号：US20120302608A1

  公开（公告）日：2012-11-29

  The present invention provides compounds of the formula below: where A, X and R1-R6 are as described herein, a pharmaceutical salt thereof, and a pharmaceutical composition containing this compound; methods of treating pain associated with osteoarthritis using one of the compounds or a pharmaceutically acceptable salt thereof, and processes for preparing the compounds.

  本发明提供了以下式的化合物： 其中A、X和R1-R6如本文所述，其药用盐，以及含有该化合物的药物组合物；使用其中一种化合物或其药用盐治疗与骨关节炎相关的疼痛的方法，以及制备这些化合物的方法。
• US8648200B2
  申请人：——

  公开号：US8648200B2

  公开（公告）日：2014-02-11
• [EN] NOVEL IMIDAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF ARTHRITIS<br/>[FR] NOUVEAUX DÉRIVÉS D'IMIDAZOLE UTILES POUR LE TRAITEMENT DE L'ARTHRITE
  申请人：LILLY CO ELI

  公开号：WO2012161965A1

  公开（公告）日：2012-11-29

  The present invention provides compounds of the formula below: where A, X and R1-R6 are as described herein, a pharmaceutical salt thereof, and a pharmaceutical composition containing this compound; methods of treating pain associated with osteoarthritis using one of the compounds or a pharmaceutically acceptable salt thereof, and processes for preparing the compounds.