The present invention relates to [ortho bi-(hetero-)aryl]-[2-(meta bi-(hetero-)aryl)-pyrrolidin-1-yl]-methanone derivatives of formula (I)
wherein R, and the rings A
1
A
2
and A
3
are as described in the description, to pharmaceutically acceptable salts thereof, to their preparation, to pharmaceutical compositions containing one or more compounds of formula (I), and to their use as pharmaceuticals, especially to their use as orexin receptor antagonists.
本发明涉及公式(I)的[ortho bi-(hetero-)aryl]-[2-(meta bi-(hetero-)aryl)-pyrrolidin-1-yl]-methanone衍
生物,其中R和环A1A2和A3如描述中所述,以及其药学上可接受的盐、其制备方法、含有一个或多个公式(I)化合物的制药组合物以及它们作为药物的用途,特别是作为促进睡眠激素受体
拮抗剂的用途。