Pd-Catalyzed Highly Regio- and Stereoselective Formation of C–C Double Bonds: An Efficient Method for the Synthesis of Benzofuran-, Dihydrobenzofuran-, and Indoline-Containing Alkenes
A highly regio- and stereoselective C–C double bond formation reactionvia Pd-catalyzed Heck-type cascade process with N-tosylhydrazones has been developed. Various N-tosylhydrazones derived from both ketones and aldehydes are found to be efficient substrates to provide di- and trisubstitutedolefins with high regio- and stereoselectivity. Furthermore, this reaction has a good functional group tolerance
A palladium-catalyzed carbothiolation via the reaction of a σ-alkyl palladium intermediate with a TIPS thioether is described. It was found that the use of Cs2CO3, (IPr)Pd(allyl)Cl, and a TIPS thioether was key to obtaining alkyl aryl and dialkyl sulfides in high yield through the reaction of a σ-alkyl palladium intermediate. The developed reaction is applicable to a wide range of substrates and thiols
描述了通过σ-烷基钯中间体与TIPS硫醚反应的钯催化的羰基硫醇化。发现使用Cs 2 CO 3,(IPr)Pd(烯丙基)Cl和TIPS硫醚是通过σ-烷基钯中间体反应以高收率获得烷基芳基和二烷基硫化物的关键。所开发的反应适用于多种底物和硫醇。
Palladium-Catalyzed Three-Component Carbocarbonation of Arynes: Expeditious Synthesis of <i>o</i>-Alkylated Arylacrylates and Stilbenes
作者:Tuanli Yao、Jiazhe Hui、Tao Liu、Tao Li
DOI:10.1021/acs.joc.0c02994
日期:2021.4.16
A palladium-catalyzed multicomponentreactioninvolving olefin-tethered aryl iodides, arynes, and electrophilic alkenes has been developed for straightforward synthesis of o-alkylated arylacrylates and stilbenes through tandem intramolecular Heck cyclization/aryne dicarbofunctionalization.
Palladium(0)-Catalyzed Heck Reaction/CH Activation/Amination Sequence with Diaziridinone: A Facile Approach to Indolines
作者:Huaiji Zheng、Yingguang Zhu、Yian Shi
DOI:10.1002/anie.201405365
日期:2014.10.13
Indolines are important moieties present in various biologically significant molecules and have attracted considerable attention in synthetic chemistry. This paper describes a Heckreaction/CHactivation/aminationsequence for forming indolines using di‐tert‐butyldiaziridinone. The reaction process likely proceeds via a pallada(II)cycle, which is converted into an indoline by oxidative addition to
二氢吲哚是存在于各种具有生物学意义的分子中的重要部分,在合成化学中引起了相当大的关注。本文描述了使用二叔丁基二氮丙啶酮形成二氢吲哚的 Heck 反应/C H 活化/胺化序列。该反应过程可能通过钯(II)循环进行,该循环通过氧化加成到二氮丙啶酮和两个随后的 C N 键形成转化为二氢吲哚。
Ligand-Controlled Palladium-Catalyzed Chemoselective Multicomponent Reaction of Olefin-Tethered Aryl Halides, Isocyanides, and Carboxylic Acids: Diversified Synthesis of Imides
ligand-controlled chemoselective synthesis of imides has been achieved. An orthogonal set of conditions has been developed for multicomponent reaction of various olefin-tethered aryl iodides, isocyanides, and carboxylic acids. Alkylimides (“cyclization on” products) via arylimidation of tethered unactivated alkenes and aryl imides (“cyclization off” products) via direct imidation of aryl iodides were