12-oxo-3,4-seco-5α-cholanetrioic acid-(3.4.24) | 501117-74-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 12-oxo-3,4-seco-5α-cholanetrioic acid-(3.4.24)
• 英文别名: 12-Oxo-3,4-seco-5α-cholantrisaeure-(3.4.24)
• CAS: 501117-74-4
• 化学式: C₂₄H₃₆O₇
• 分子量: 436.546
• InChiKey: FCLKILCSSINPNA-JHTPKFRMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.09
• 重原子数：
  31.0
• 可旋转键数：
  8.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  128.97
• 氢给体数：
  3.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  12-oxo-3,4-seco-5α-cholanetrioic acid-(3.4.24) 生成 3,12-dioxo-A-nor-5ξ-cholanoic acid-(24)
  参考文献：
  名称：

  Genetic and morphometric comparison betweenSorex arunchi Lapini and Testone, 1998, and other shrews from Italy

  摘要：

  The results of allozymic, morphologic and morphometric studies performed on three parapatric shrews of the genus Sorex from northern Italy are presented. These data clearly indicate: (1) Sorex samniticus is genetically well differentiated from S. araneus and S, arunchi, displaying a high mean value of genetic distance in comparison with the other two species (D = 0.463). (2) S, araneus and S. arunchi display low values of genetic distance (D = 0.007) and the latter shows lower levels of genetic variability. Altough no fixed allele difference was observed, an exclusive allele (Lap-2(96)) is present in S. arunchi at low frequence, another one (Pgm-1(96)) is rare in S. araneus and quite frequent in S. arunchi, and several alleles (12) of S. araneus are missing in S. arunchi. In S. araneus some of these alleles are quite frequent. (3) Strong morphometric differences between S. araneus and S. arunchi permit to distinguish these parapatric shrews with great accuracy, also in some cases of marginal sympatry. These evidences support the hypothesis that S, arunchi might be a recent (end of Pleistocene-lower Holocene) relict of the subgenus Sorex s. s.

  DOI：

  10.1007/bf03192441
• 作为产物：
  描述：

  去氧胆酸 在 硝酸 作用下， 250.0~380.0 ℃ 、1.6 kPa 条件下， 生成 12-oxo-3,4-seco-5α-cholanetrioic acid-(3.4.24)
  参考文献：
  名称：

  Wieland; Kulenkampff, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1919, vol. 108, p. 295,300

  摘要：

  DOI：

文献信息

• Borsche, Chemische Berichte, 1924, vol. 57, p. 1435
  作者：Borsche

  DOI：——

  日期：——
• Shimizu; Kazuno, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1934, vol. 224, p. 155,157
  作者：Shimizu、Kazuno

  DOI：——

  日期：——
• Wieland, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1925, vol. 142, p. 191,195
  作者：Wieland

  DOI：——

  日期：——
• A physician workforce planning model applied to Canadian anesthesiology: assessment of needs
  作者：Robert J. Byrick、Douglas Craig、Franco Carli

  DOI：10.1007/bf03017442

  日期：2002.8

  Purpose: A human resource planning model for anesthesiology is described.Methods: The model uses 'per capita' expenditure for anesthesiologists in Quebec, as a measure of clinical services provided to different age/gender groups. The future demand for anesthesia services is calculated as the product of 'per capita' expenditure and the population projections to a future date. Future demand was converted into full-time equivalent (FTE) providers required, by dividing by the annual 'units of service' optimally delivered by one FTE anesthesiologist. The pattern of age/gender (demographic) consumption of anesthesia services in Quebec was compared with data from Ontario to validate its use in a planning model. The model was then applied to all provinces and territories.Results: The 'per capita' expenditures on anesthesia services in Quebec and Ontario showed a regular pattern. Using the model, the estimated 1999 demand for FTE anesthesiologists to provide clinical services in Quebec is 546 and 669 for 2016. When non-clinical demands were included, we estimated that Quebec's total demand will increase to approximately 730 FTEs in 2016. Similar estimates are made for all provinces. The population increase anticipated is 17.9% but the increase in FFE demand in Canada is 30.9%.Conclusion: The model showed that the cause of the increased FTE demand for anesthesiologists is a combination of increased population and its demographic composition. The relative impact of each of these factors varies in different provinces. Effective specialty-specific planning models can be designed but they need ongoing committed resources and personnel for their usefulness to be maximized.
• Wieland; Ertel; Schoenberger, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1931, vol. 197, p. 31,35, 38
  作者：Wieland、Ertel、Schoenberger

  DOI：——

  日期：——