4-[4-(4-甲氧基苯基)-5-[[[3-(4-甲基苯基)-1,2,4-恶二唑-5-基]甲基]硫基]-4H-1,2,4-三唑-3-基]-吡啶 | 863405-60-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 4-[4-(4-甲氧基苯基)-5-[[[3-(4-甲基苯基)-1,2,4-恶二唑-5-基]甲基]硫基]-4H-1,2,4-三唑-3-基]-吡啶
• 英文名称: JW74
• 英文别名: 4-[4-(4-methoxyphenyl)-5-({[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-4H-1,2,4-triazol-3-yl]pyridine；5-[[4-(4-methoxyphenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-3-(4-methylphenyl)-1,2,4-oxadiazole
• CAS: 863405-60-1
• 化学式: C₂₄H₂₀N₆O₂S
• mdl: MFCD07048962
• 分子量: 456.528
• InChiKey: KRIKILRRJCIWNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  117
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• [EN] AZOLE DERIVATIVES AS WTN PATHWAY INHIBITORS<br/>[FR] DÉRIVÉS D'AZOLE EN TANT QU'INHIBITEURS DE LA VOIE WNT
  申请人：OSLO UNIVERSITY HOSPITAL HF

  公开号：WO2010139966A1

  公开（公告）日：2010-12-09

  The present invention relates to new compounds of formula I, to processes for their preparation, to pharmaceutical formulations containing such compounds and to their use in therapy. Such compounds find particular use in the treatment and/or prevention of conditions or diseases which are affected by over-activation of signaling in the Wnt pathway. For example, these may be used in preventing and/or retarding proliferation of tumor cells, for example carcinomas such as colon carcinomas.

  本发明涉及公式I的新化合物，涉及其制备过程，含有这种化合物的药物配方以及它们在治疗中的应用。这些化合物在治疗和/或预防受到Wnt信号通路过度激活影响的疾病或病症中发挥特定作用。例如，它们可用于预防和/或延缓肿瘤细胞的增殖，例如结肠癌等癌症。
• Azole Derivatives as WTN Pathway Inhibitors
  申请人：Holsworth Daniel

  公开号：US20120208828A1

  公开（公告）日：2012-08-16

  The present invention relates to new compounds of formula I, to processes for their preparation, to pharmaceutical formulations containing such compounds and to their use in therapy. Such compounds find particular use in the treatment and/or prevention of conditions or diseases which are affected by over-activation of signaling in the Wnt pathway. For example, these may be used in preventing and/or retarding proliferation of tumor cells, for example carcinomas such as colon carcinomas.

  本发明涉及公式I的新化合物，其制备过程，含有这些化合物的制药配方以及它们在治疗中的应用。这些化合物在防治或治疗Wnt通路信号过度激活引起的疾病或症状方面具有特殊用途。例如，它们可以用于预防和/或延缓肿瘤细胞的增殖，例如结肠癌等癌症的治疗。
• Antiviral axin stabilizer
  申请人：The Board of Regents for Oklahoma State University

  公开号：US10064862B2

  公开（公告）日：2018-09-04

  Methods and compositions for preventing and/or treating viral infections are provided. The methods involve administering an agent that stabilizes or enhances Axin1 activity, e.g. and agent that inhibits tankyrase. Administration of the agent stimulates or increases interferon activity, thereby preventing or lessening at least one symptom of virus infection. The virus infection may be caused by a respiratory virus such as influenza vims.

  提供了预防和/或治疗病毒感染的方法和组合物。这些方法包括施用稳定或增强 Axin1 活性的制剂，例如抑制 tankyrase 的制剂。给药可刺激或增加干扰素活性，从而预防或减轻病毒感染的至少一种症状。病毒感染可由呼吸道病毒引起，如流感病毒。
• Anti-CD70 combination therapy
  申请人：University of Bern

  公开号：US10391168B1

  公开（公告）日：2019-08-27

  Provided are methods and compositions for the treatment of a BCR-ABL1 related disorder (e.g., chronic myelogenous leukemia) using a therapeutic combination of a WNT signaling pathway inhibitor and a BCR-ABL1 tyrosine kinase inhibitor.

  本文提供了使用WNT信号通路抑制剂和BCR-ABL1酪氨酸激酶抑制剂的治疗组合来治疗BCR-ABL1相关疾病（如慢性粒细胞白血病）的方法和组合物。
• Methods for treating diseases related to the wnt pathway
  申请人：Sandia Corporation

  公开号：US10624949B1

  公开（公告）日：2020-04-21

  The present invention relates to methods for treating a disease, in which the disease arises from dysregulation of the Wnt signaling pathway. In some instances, the disease can be treated by administering a Wnt pathway inhibitory compound. In other instances, the method optionally includes conducting a genome-wide screening to determine one or more genes resulting in a reduced disease state and then identifying the gene(s) as being involved in the Wnt signaling pathway.

  本发明涉及治疗疾病的方法，其中疾病是由 Wnt 信号通路失调引起的。在某些情况下，可以通过施用抑制 Wnt 通路的化合物来治疗疾病。在其他情况下，该方法可选地包括进行全基因组筛选，以确定导致疾病状态降低的一个或多个基因，然后确定这些基因参与Wnt信号通路。