5-<2-Chlor-phenyl>-1,3-dihydro-7-methyl-2H-1,4-benzodiazepin-on-(2) | 6021-36-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 5-<2-Chlor-phenyl>-1,3-dihydro-7-methyl-2H-1,4-benzodiazepin-on-(2)
• 英文别名: 5-<2-Chlorphenyl>-7-methyl-3H-1.4-benzodiazepin-2(1H)-on；5-(2-chloro-phenyl)-7-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one；5-(2-Chlorophenyl)-7-methyl-1,3-dihydro-1,4-benzodiazepin-2-one
• CAS: 6021-36-9
• 化学式: C₁₆H₁₃ClN₂O
• 分子量: 284.745
• InChiKey: ZVKFBLIDCCXOFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Use of Clonazepam in Combination with Antibiotic in the Treatment of Bacterially Induced Meningitis
  申请人：COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

  公开号：US20160082016A1

  公开（公告）日：2016-03-24

  The present invention relates to the use of a well-known benzodiazepine compound, namely clonazepam, in combination with antibiotic agents, for treating bacterially induced meningitis.

  本发明涉及使用一种广泛应用的苯二氮平类化合物，即氯硝西泮，与抗生素联合治疗细菌引起的脑膜炎。
• COMPOSITIONS OF PHARMACEUTICAL ACTIVES CONTAINING DIETHYLENE GLYCOL MONOETHYL ETHER OR OTHER ALKYL DERIVATIVES
  申请人：THEMIS MEDICARE LIMITED

  公开号：US20140296191A1

  公开（公告）日：2014-10-02

  The present invention relates to pharmaceutical compositions of various pharmaceutical actives, especially lyophilic and hydrophilic actives containing Diethylene glycol monoethyl ether or other alkyl derivatives thereof as a primary vehicle and/or to pharmaceutical compositions utilizing Diethylene glycol monoethyl ether or other alkyl derivatives thereof as a primary vehicle or as a solvent system in preparation of such pharmaceutical compositions. The pharmaceutical compositions of the present invention are safe, non-toxic, exhibits enhanced physical stability compared to conventional formulations containing such pharmaceutical actives and are suitable for use as injectables for intravenous and intramuscular administration, as well as for use as a preformed solution/liquid for filling in and preparation of capsules, tablets, nasal sprays, gargles, dermal applications, gels, topicals, liquid oral dosage forms and other dosage forms.
• US9827315B2
  申请人：——

  公开号：US9827315B2

  公开（公告）日：2017-11-28