4-[1-(4-Chlorophenyl)-5-(4-methoxyphenyl)pyrazol-3-yl]-4-hydroxycyclohexan-1-one | 1224948-56-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[1-(4-Chlorophenyl)-5-(4-methoxyphenyl)pyrazol-3-yl]-4-hydroxycyclohexan-1-one
• CAS: 1224948-56-4
• 化学式: C₂₂H₂₁ClN₂O₃
• 分子量: 396.873
• InChiKey: MFIXBTSPMUKOJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  64.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• CYCLOHEXANE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
  申请人：Toray Industries, Inc.

  公开号：EP2341047A1

  公开（公告）日：2011-07-06

  The present invention aims to provide a compound having a strong analgesic action against both nociceptive pain and neuropathic pain and having less side effects, and a medical use thereof. The present invention provides cyclohexane derivatives represented by the following compound, or pharmaceutically acceptable salts thereof or prodrugs thereof.

  本发明旨在提供一种对痛觉痛和神经病理性痛均有较强镇痛作用且副作用较小的化合物及其医疗用途。本发明提供以下列化合物为代表的环己烷衍生物，或其药学上可接受的盐或其原药。
• THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR FIBROMYALGIA
  申请人：Toray Industries, Inc.

  公开号：EP2554541A1

  公开（公告）日：2013-02-06

  An object of the present invention is to provide a therapeutic agent or prophylactic agent which has an analgesic effect on both nociceptive pain and neuropathic pain and is effective in treatment of fibromyalgia. The present invention provides a therapeutic agent or prophylactic agent for fibromyalgia, said agent comprising as an effective ingredient a cyclohexane derivative exemplified by the formula below, or a pharmaceutically acceptable salt thereof or a prodrug thereof.

  本发明的目的是提供一种治疗剂或预防剂，该治疗剂或预防剂对痛觉痛和神经病理性痛均有镇痛作用，并能有效治疗纤维肌痛。本发明提供了一种纤维肌痛的治疗剂或预防剂，所述治疗剂包括作为有效成分的下式示例的环己烷衍生物，或其药学上可接受的盐或其原药。
• THERAPEUTIC AGENT AND PREVENTATIVE AGENT FOR ALZHEIMER'S DISEASE
  申请人：Toray Industries, Inc.

  公开号：EP2565184A1

  公开（公告）日：2013-03-06

  An object of the present invention is to provide a therapeutic agent or prophylactic agent for Alzheimer's disease, which has an effect to inhibit or delay the progress of Alzheimer's disease and exhibits a long-lasting therapeutic effect on Alzheimer's disease even when used for a long period of time. The present invention provides a therapeutic agent or prophylactic agent for Alzheimer's disease, said agent comprising as an effective ingredient a cyclohexane derivative exemplified by the formula below, or a pharmaceutically acceptable salt thereof or a prodrug thereof.

  本发明的目的是提供一种阿尔茨海默病的治疗剂或预防剂，该治疗剂或预防剂具有抑制或延缓阿尔茨海默病进展的作用，即使长期使用也能对阿尔茨海默病产生持久的治疗效果。本发明提供了一种阿尔茨海默病的治疗剂或预防剂，所述治疗剂作为有效成分包括如下式所示的环己烷衍生物，或其药学上可接受的盐或其原药。
• THERAPEUTIC AGENT OR PREVENTIVE AGENT FOR URINE COLLECTION DISORDER
  申请人：Hareyama Nana

  公开号：US20130041157A1

  公开（公告）日：2013-02-14

  A therapeutic agent or prophylactic agent is effective for therapy of urine storage disorders, by which agent improvement of side effects due to an anticholinergic action is attained as well as which agent also has an analgesic effect. The agent includes as an effective ingredient a cyclohexane derivative exemplified by the formula below, a pharmaceutically acceptable salt thereof, or a prodrug thereof.
• US8349874B2
  申请人：——

  公开号：US8349874B2

  公开（公告）日：2013-01-08