(S)-2-((benzyloxycarbonyl)amino)-4-(1-amino-2-pyrrolyl)butanoic acid | 140677-46-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-2-((benzyloxycarbonyl)amino)-4-(1-amino-2-pyrrolyl)butanoic acid
• 英文别名: (S)-2-[(benzyloxycarbonyl)amino]-4-(1-amino-2-pyrrolyl)butanoic acid；(2S)-4-(1-aminopyrrol-2-yl)-2-(phenylmethoxycarbonylamino)butanoic acid
• CAS: 140677-46-9
• 化学式: C₁₆H₁₉N₃O₄
• 分子量: 317.345
• InChiKey: BAXWFVNONHRIOB-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.51
• 重原子数：
  23.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  106.58
• 氢给体数：
  3.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  (S)-2-((benzyloxycarbonyl)amino)-4-(1-amino-2-pyrrolyl)butanoic acid 在 palladium on activated charcoal sodium hydroxide 、 氢气 、 sodium ethanolate 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 为溶剂， 25.0~40.0 ℃ 、101.33 kPa 条件下， 反应 3.5h， 生成 (3S,1'S)-3-((1-carboxy-3-phenylpropyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepine-1-acetic acid
  参考文献：
  名称：

  Asymmetric synthesis of pyrrolo[1,2-b][1,2]diazepine derivatives as potential antihypertensive drugs

  摘要：

  The asymmetric synthesis of compound 1, with Potential angiotensin-converting enzyme inhibitory activity, is reported. From the chiral precursor 5, readily available from L-glutamic acid, two strategies to the key heterocyclic system pyrrolo[1,2-b][1,2]diazepine have been developed. The first one is based on the formation of the pyrrole nucleus in the early stages of the synthesis. The second strategy is based on the formation of the pyrrole in the final stages and can be regarded as a two-step Paal-Knorr N-aminopyrrole synthesis, in which intermediate N-protection is unnecessary.

  DOI：

  10.1021/jo00039a007
• 作为产物：
  描述：

  (S)-4-<2'-(Chloroformyl)ethyl>-5-oxooxazolidin-3-carbonsaeure-benzylester 在 盐酸 、 sodium hydroxide 、 一水合肼 、 magnesium 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 4.75h， 生成 (S)-2-((benzyloxycarbonyl)amino)-4-(1-amino-2-pyrrolyl)butanoic acid
  参考文献：
  名称：

  Asymmetric synthesis of pyrrolo[1,2-b][1,2]diazepine derivatives as potential antihypertensive drugs

  摘要：

  The asymmetric synthesis of compound 1, with Potential angiotensin-converting enzyme inhibitory activity, is reported. From the chiral precursor 5, readily available from L-glutamic acid, two strategies to the key heterocyclic system pyrrolo[1,2-b][1,2]diazepine have been developed. The first one is based on the formation of the pyrrole nucleus in the early stages of the synthesis. The second strategy is based on the formation of the pyrrole in the final stages and can be regarded as a two-step Paal-Knorr N-aminopyrrole synthesis, in which intermediate N-protection is unnecessary.

  DOI：

  10.1021/jo00039a007