2-chloro-6-fluoro-N-(2-(2-methylpyrimidin-5-yl)-2-(pyridin-4-yl)ethyl)benzamide | 1600495-81-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-6-fluoro-N-(2-(2-methylpyrimidin-5-yl)-2-(pyridin-4-yl)ethyl)benzamide
• 英文别名: 2-chloro-6-fluoro-N-(2-(2-methylpyrimidin-5-yl)-2-(pyridin-4-yl)ethyl)benz amide；2-chloro-6-fluoro-N-[2-(2-methylpyrimidin-5-yl)-2-pyridin-4-ylethyl]benzamide
• CAS: 1600495-81-5
• 化学式: C₁₉H₁₆ClFN₄O
• 分子量: 370.814
• InChiKey: XXMSRMYYFQGTNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  67.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氯-6-氟苯甲酸 、 2-(2-Methylpyrimidin-5-yl)-2-(pyridin-4-yl)ethanamine 生成 2-chloro-6-fluoro-N-(2-(2-methylpyrimidin-5-yl)-2-(pyridin-4-yl)ethyl)benzamide
  参考文献：
  名称：

  Benzamides

  摘要：

  本发明涉及含苯酰胺化合物，其抑制P2X7受体。

  公开号：

  US09102591B2

文献信息

• Benzamides-containing compounds and their use in the treatment of epilepsy
  申请人：MINDIMMUNE THERAPEUTICS, INC.

  公开号：US10238654B2

  公开（公告）日：2019-03-26

  The present invention is directed to benzamide-containing compounds of formula I or pharmaceutically acceptable salts thereof which inhibit the P2X7 receptor, and their use in the treatment of epilepsy.

  本发明涉及式 I 的含苯甲酰胺化合物 或其药学上可接受的盐，它们能抑制 P2X7 受体，并可用于治疗癫痫。
• BENZAMIDES
  申请人：H. Lundbeck A/S

  公开号：EP2906546B1

  公开（公告）日：2018-01-10
• Benzamides-Containing Compounds and Their Use in the Treatment of Epilepsy
  申请人：H. Lundbeck A/S

  公开号：US20170202836A1

  公开（公告）日：2017-07-20

  The present invention is directed to benzamide-containing compounds of formula I or pharmaceutically acceptable salts thereof which inhibit the P2X 7 receptor, and their use in the treatment of epilepsy.
• BENZAMIDES-CONTAINING COMPOUNDS AND THEIR USE IN THE TREATMENT OF DEPRESSION
  申请人：MINDIMMUNE THERAPEUTICS, INC.

  公开号：US20200054630A1

  公开（公告）日：2020-02-20

  The present invention is directed to benzamide-containing compounds of formula I or pharmaceutically acceptable salts thereof which inhibit the P2X 7 receptor, and their use in the treatment of depression.
• US9102591B2
  申请人：——

  公开号：US9102591B2

  公开（公告）日：2015-08-11