Boc-His(Boc)-Gly-OH | 415719-35-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-His(Boc)-Gly-OH
• 英文别名: Glycine, N,1-bis[(1,1-dimethylethoxy)carbonyl]-L-histidyl-；2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-[1-[(2-methylpropan-2-yl)oxycarbonyl]imidazol-4-yl]propanoyl]amino]acetic acid
• CAS: 415719-35-6
• 化学式: C₁₈H₂₈N₄O₇
• 分子量: 412.443
• InChiKey: WLXNEIFGQYAMPL-LBPRGKRZSA-N

物化性质

• 熔点：
  134-135 °C(Solv: ethyl acetate (141-78-6); ethyl ether (60-29-7))
• 密度：
  1.27±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  29
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  149
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Boc-His(Boc)-Gly-OH 在 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 三乙胺 、 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 24.5h， 生成
  参考文献：
  名称：

  l-Histidyl-glycyl-glycyl-l-histidine. Amino-acid structuring of the bleomycin-type pentadentate metal-binding environment capable of efficient double-strand cleavage of plasmid DNA

  摘要：

  A tetrapeptide, L-histidyl-glycyl-glycyl-L-histidine (HGGH), was synthesized and the pUC19 plasmid DNA cleaving activity by copper(II) complex of HGGH (Cu(II)-HGGH) was investigated. Cu(II)-HGGH showed bleomycin-like DNA cleaving activity and, at 50 nM, converted a supercoiled DNA efficiently to a linear DNA in the presence of 500 mu M H2O2/sodium ascorbate through an oxidative pathway. (C) 2015 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bioorg.2015.06.007
• 作为产物：
  描述：

  Boc-His(Boc)-OH 二环己基铵盐 在 5%-palladium/activated carbon 、 氢气 、 三乙胺 作用下， 以 乙醇 、 乙腈 为溶剂， 反应 26.0h， 生成 Boc-His(Boc)-Gly-OH
  参考文献：
  名称：

  l-Histidyl-glycyl-glycyl-l-histidine. Amino-acid structuring of the bleomycin-type pentadentate metal-binding environment capable of efficient double-strand cleavage of plasmid DNA

  摘要：

  A tetrapeptide, L-histidyl-glycyl-glycyl-L-histidine (HGGH), was synthesized and the pUC19 plasmid DNA cleaving activity by copper(II) complex of HGGH (Cu(II)-HGGH) was investigated. Cu(II)-HGGH showed bleomycin-like DNA cleaving activity and, at 50 nM, converted a supercoiled DNA efficiently to a linear DNA in the presence of 500 mu M H2O2/sodium ascorbate through an oxidative pathway. (C) 2015 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bioorg.2015.06.007

文献信息

• l-Histidyl-glycyl-glycyl-l-histidine. Amino-acid structuring of the bleomycin-type pentadentate metal-binding environment capable of efficient double-strand cleavage of plasmid DNA
  作者：Satomi Ida、Kana Iwamaru、Mikako Fujita、Yoshinari Okamoto、Yuri Kudo、Hiromasa Kurosaki、Masami Otsuka

  DOI：10.1016/j.bioorg.2015.06.007

  日期：2015.10

  A tetrapeptide, L-histidyl-glycyl-glycyl-L-histidine (HGGH), was synthesized and the pUC19 plasmid DNA cleaving activity by copper(II) complex of HGGH (Cu(II)-HGGH) was investigated. Cu(II)-HGGH showed bleomycin-like DNA cleaving activity and, at 50 nM, converted a supercoiled DNA efficiently to a linear DNA in the presence of 500 mu M H2O2/sodium ascorbate through an oxidative pathway. (C) 2015 Elsevier Inc. All rights reserved.