[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-dimethoxy-sulfidophosphanium | 186425-62-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-dimethoxy-sulfidophosphanium
• CAS: 186425-62-7
• 化学式: C₈H₁₉N₂O₃PS
• 分子量: 254.29
• InChiKey: RKBOZXDHKBJALJ-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-dimethoxy-sulfidophosphanium 在 sodium hydroxide 、 TEA 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 ((S)-1-Carbamoyl-3-methyl-butyl)-thiophosphoramidic acid S-benzyl ester O-methyl ester
  参考文献：
  名称：

  Synthesis of P-chiral, phosphorothioic acid analogs of N-phospholeucinamide

  摘要：

  A diastereomeric mixture of R(p)- and S-p- N-[O-methyl phosphorothioic acid]leucinamides were synthesized by thiophosphorlation of leucinamide followed by monodealkylation of the phosphate methyl ester. Individual diastereomers were prepared by a sequence utilizing selective protection of the thioic acid moiety as the S-benzyl group, chromatographic separation, and deprotection. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0040-4039(96)02107-7
• 作为产物：
  描述：

  亮氨酰胺 、 二甲基硫代磷酰氯 在 TEA 作用下， 以 四氢呋喃 为溶剂， 以70%的产率得到[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-dimethoxy-sulfidophosphanium
  参考文献：
  名称：

  Synthesis of P-chiral, phosphorothioic acid analogs of N-phospholeucinamide

  摘要：

  A diastereomeric mixture of R(p)- and S-p- N-[O-methyl phosphorothioic acid]leucinamides were synthesized by thiophosphorlation of leucinamide followed by monodealkylation of the phosphate methyl ester. Individual diastereomers were prepared by a sequence utilizing selective protection of the thioic acid moiety as the S-benzyl group, chromatographic separation, and deprotection. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0040-4039(96)02107-7