3-[2-(4-bromophenyl)triazol-4-yl]-1-phenylprop-2-en-1-one | 150981-46-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[2-(4-bromophenyl)triazol-4-yl]-1-phenylprop-2-en-1-one
• CAS: 150981-46-7
• 化学式: C₁₇H₁₂BrN₃O
• 分子量: 354.206
• InChiKey: CUOFYTVPJGVXPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.93
• 重原子数：
  22.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  47.78
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  3-[2-(4-bromophenyl)triazol-4-yl]-1-phenylprop-2-en-1-one 在 potassium carbonate 作用下， 以 乙醇 为溶剂， 反应 15.0h， 生成
  参考文献：
  名称：

  Mokhtar, Hassan M.; Faildallah, Hassan M.; Moustafa, Jehan M., Pakistan Journal of Scientific and Industrial Research, 1992, vol. 35, # 11, p. 428 - 433

  摘要：

  DOI：
• 作为产物：
  描述：

  苯乙酮 、 2-(p-bromophenyl)-4-formyl-1,2,3-triazole 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以70%的产率得到3-[2-(4-bromophenyl)triazol-4-yl]-1-phenylprop-2-en-1-one
  参考文献：
  名称：

  Mokhtar, Hassan M.; Faildallah, Hassan M.; Moustafa, Jehan M., Pakistan Journal of Scientific and Industrial Research, 1992, vol. 35, # 11, p. 428 - 433

  摘要：

  DOI：

文献信息

• Catalytic conjugate addition of indole to α,β-unsaturated ketones by Co(ClO4)2·6H2O/bis-Schiff base complexes
  作者：Yong Hai Hui、Chun Mei Chen、Zheng Feng Xie

  DOI：10.1016/j.cclet.2012.03.015

  日期：2012.5

  Co(ClO4)2·6H2O/bis-Schiff base complexes promoted the conjugate addition of indole to α,β-unsaturated ketones under mild conditions, giving the corresponding addition products with high yields. And the complex has been characterized with XRD and IR.

  Co（ClO 4）2 ·6H 2 O /双-席夫碱配合物在温和条件下促进了吲哚向α，β-不饱和酮的共轭加成反应，从而以高收率得到了相应的加成产物。并用XRD和IR对复合物进行了表征。
• An Efficient Synthesis of 1-Aryl-3-(indole-3-yl)-3-(2-aryl-1,2,3-triazol-4-yl)propan-1-one Catalyzed by a Brønsted Acid Ionic Liquid
  作者：Chen-Jiang Liu、Chuan-Ji Yu

  DOI：10.3390/molecules15129197

  日期：——

  An efficient synthesis of novel 1-aryl-3-(indole-3-yl)-3-(2-aryl-1,2,3-triazol-4-yl)propan-1-ones from indoles and 1-aryl-3-(2-aryl-1,2,3-triazol-4-yl)propan-1-one using a Brønsted acid ionic liquid [Sbmim][HSO4] as catalyst is described. Satisfactory results with excellent yields and short reaction time were obtained in the experiments. The catalyst could be recovered conveniently and reused efficiently.

  介绍了一种以吲哚和 1-芳基-3-(2-芳基-1,2,3-三唑-4-基)丙-1-酮为原料，使用布氏酸离子液体 [Sbmim][HSO4]为催化剂，高效合成新型 1-芳基-3-(吲哚-3-基)-3-(2-芳基-1,2,3-三唑-4-基)丙-1-酮的方法。实验结果令人满意，产率高，反应时间短。催化剂可以方便地回收并有效地重复使用。
• Synthesis and Spectral Characterization of Some Novel Thiazolyl-Pyrazoline Derivatives Containing 1,2,3-Triazole Moiety
  作者：Hai Shi、Fang-Ming Liu、Song-Wei Shen

  DOI：10.1080/10426507.2010.494647

  日期：2011.1.31

  A series of novel 3-aryl-5-(2-aryl-1,2,3-triazol-4-yl)-1-(4-aryl-2-thiazoyl)pyrazolines 6a-6r were synthesized using 2-aryl-4-formyl-1,2,3-triazoles 1a, b as the starting materials. Thus, reacting 1a, b with 1-arylethanones 2a-2c gave 1-aryl-3-(2-aryl-1,2,3-triazol4- yl)-2-propen-1-ones 3a-3f. The reaction of the latter with thiosemicarbazide afforded 3-aryl-5-(2-aryl-1,2,3-triazol-4-yl)-1-thiocarbamoyl-pyrazolines 4a-4f, which condensed with 2-bromo-1-arylethanones 5a-5c to afford the target compounds 6a-6r. The chemical structures of the compounds were verified by means of their IR, (1)H NMR, ESI-MS spectroscopic data, and elemental analysis.