5-Mercapto-1-phenyl-1,2,3-triazol | 90004-47-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-Mercapto-1-phenyl-1,2,3-triazol
• 英文别名: 3-phenyl-2,3-dihydro-[1,2,3]triazole-4-thione
• CAS: 90004-47-0
• 化学式: C₈H₇N₃S
• 分子量: 177.23
• InChiKey: LXMPJPJANHMZCZ-UHFFFAOYSA-N

文献信息

• [EN] 1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS<br/>[FR] DÉRIVÉS D'HÉTÉROCYCLYLE SUBSTITUÉS PAR UN 1-PHÉNYLE ET LEUR UTILISATION EN TANT QUE MODULATEURS DES RÉCEPTEURS DE LA PROSTAGLANDINE D2
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2012004722A1

  公开（公告）日：2012-01-12

  302 Abstract The present invention relates to 1-phenyl-substituted heterocyclyl derivatives of the formula (I), O Y R 5 R 6 N R 2 R 3 R 4 X Z R 1 R 7 R 7 R 10 n (I) 5 wherein X, Y, Z, n, R 1, R 2, R 3, R 4, R 5, R 6, R 7 and R 10 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D 2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation. 10

  本发明涉及公式(I)的1-苯基取代的杂环基衍生物，其中X、Y、Z、n、R1、R2、R3、R4、R5、R6、R7和R10如描述中所述，并且它们作为前列腺素受体调节剂的用途，特别是作为前列腺素D2受体调节剂，在治疗各种前列腺素介导的疾病和紊乱中的用途，以及含有这些化合物的制药组合物和其制备方法。
• INTERMEDIATES FOR THE PREPARATION OF HMG COA REDUCTASE INHIBITORS AND PROCESSES FOR THE PREPARATION THEREOF
  申请人：Dwivedi Shriprakash Dhar

  公开号：US20130158263A1

  公开（公告）日：2013-06-20

  A compound of Formula (1), is disclosed wherein P 1 and P 2 are alcohol protecting groups or 1,3-diol protecting group, R is selected from: wherein R 4 a is selected from alkyl, aryl, arylalkyl and cycloalkyl, Rc is selected from H, alkyl, aryl, alkaoxy, haloalkyl, monohaloalkyloxy, and dihaloalkyloxy, Rd is selected from alkyl, aryl, arylalkyl, CF 3 , halo and NO 2 and X is selected from O, N—H, N-alkyl and S, Ra and Rb are same or different and each represents hydrogen, an alkyl group of 1 to 12 carbon atoms, an aryl group of 6 to 12 carbon atoms, or an aralkyl group of 7 to 12 carbon atoms.

  公开了一种化合物，其化学式为（1），其中P1和P2是醇保护基或1,3-二醇保护基，R选自：其中R4a选自烷基、芳基、芳基烷基和环烷基，Rc选自H、烷基、芳基、烷氧基、卤代烷基、单卤代烷氧基和双卤代烷氧基，Rd选自烷基、芳基、芳基烷基、CF3、卤素和NO2，X选自O、N-H、N-烷基和S，Ra和Rb相同或不同，每个代表氢、1至12个碳原子的烷基、6至12个碳原子的芳基，或7至12个碳原子的芳基烷基。
• AMPK-ACTIVATING HETEROCYCLIC COMPOUNDS AND METHODS FOR USING THE SAME
  申请人：Goff Dane

  公开号：US20140315884A1

  公开（公告）日：2014-10-23

  Disclosed are substituted pyridine compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure wherein E, J, T, the ring system denoted by “B”, T, R 3 , R 4 , w and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.

  本发明涉及取代吡啶化合物，以及制药组合物和使用方法。其中一种实施例是具有以下结构的化合物，其中E、J、T、表示为“B”的环系统、T、R3、R4、w和x如本文所述。在某些实施例中，本文所披露的化合物可以激活AMPK途径，并可用于治疗与代谢有关的疾病和症状。
• 1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS
  申请人：Aissaoui Hamed

  公开号：US20130109685A1

  公开（公告）日：2013-05-02

  The present invention relates to 1-phenyl-substituted heterocyclyl derivatives of the formula (I), wherein X, Y, Z, n, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 10 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D 2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.

  本发明涉及公式（I）中1-苯基取代的杂环基衍生物，其中X、Y、Z、n、R1、R2、R3、R4、R5、R6、R7和R10如描述中所述，以及它们在各种前列腺素介导的疾病和疾病的治疗中作为前列腺素受体调节剂，特别是作为前列腺素D2受体调节剂的用途，以及包含这些化合物的制药组合物和它们的制备方法。
• Optical film, polarizing plate and display
  申请人：Murakami Takashi

  公开号：US20060078754A1

  公开（公告）日：2006-04-13

  A method for producing an optical film comprising steps of mixing a heated and molten cellulose ester having an acylated degree for from 2.5 to 2.9 and at least one of a UV absorbent having at least two benzotriazole skeletons and a UV absorbent having a weight average molecular weight of from 2,000 to 50,000 to form a mixture, and extruding the mixture to form a film.

  一种生产光学薄膜的方法，包括以下步骤：将加热熔融的、酰化度为 2.5 至 2.9 的纤维素酯与至少具有两个苯并三唑骨架的紫外线吸收剂和重量平均分子量为 2,000 至 50,000 的紫外线吸收剂中的至少一种混合成混合物，并将混合物挤压成膜。