3-(4-Fluorophenyl)-4-methyl-1H-pyrazole | 916792-26-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(4-Fluorophenyl)-4-methyl-1H-pyrazole
• 英文别名: 5-(4-fluorophenyl)-4-methyl-1H-pyrazole
• CAS: 916792-26-2
• 化学式: C₁₀H₉FN₂
• mdl: MFCD01940436
• 分子量: 176.19
• InChiKey: DSDCWXOENGTWKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS
  申请人：Gilead Sciences, Inc.

  公开号：US20140336190A1

  公开（公告）日：2014-11-13

  This application relates to chemical compounds which may act as inhibitors of; or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R 1a , R 1b , R 2 , R 2b , R 3 , R 4a , R 4b , and R 5 are described herein.

  这个应用涉及可能作为抑制剂的化合物；或者可能以其他方式调节溴结构域含蛋白的活性，包括溴结构域含蛋白4（BRD4），以及含有这些化合物的组合物和配方，以及使用和制备这些化合物的方法。化合物包括式（I）的化合物 其中R 1a ，R 1b ，R 2 ，R 2b ，R 3 ，R 4a ，R 4b 和R 5 如本文所述。
• [EN] FLUOROPHENYL PYRAZOL COMPOUNDS<br/>[FR] COMPOSÉS FLUOROPHÉNYL-PYRAZOLE
  申请人：LILLY CO ELI

  公开号：WO2015089800A1

  公开（公告）日：2015-06-25

  The present invention provides a compound of the Formula (I), wherein X is selected from the group consisting of (II); R is selected from the group consisting of H and CH3; R1 is selected from the group consisting of H, CH3, F, Cl, OCH3, C(O)OH, C(O)NH2 and (III); or a pharmaceutically acceptable salt thereof.

  本发明提供了一种式（I）的化合物，其中X选自（II）组成的群；R选自H和CH3组成的群；R1选自H、 、F、Cl、O 、C(O)OH、C(O)NH2和（III）组成的群；或其药用可接受的盐。
• Imine Compound
  申请人：Saito Shiuji

  公开号：US20080312435A1

  公开（公告）日：2008-12-18

  An imine compound represented by the formula: wherein A represents a heterocyclic group; R 1 , R 2 , an R 3 each represent a hydrogen atom, a halogen atom, a C 1-10 alkyl group optionally substituted with an aryl group(s) substituted with a halogen atom(s), a C 3-10 cycloalkyl group, a C 1-6 haloalkyl group, a C 1-10 alkoxy group, etc.; R 4 represents an optionally substituted C 1-10 alkyl, C 2-6 alkenyl, or aryl group; R 5 represents a hydrogen atom, a C 1-10 alkoxy group, a C 1-6 haloalkyl group, an optionally substituted C 1-10 alkyl or C 2-6 alkenyl group, an optionally substituted aryl or heterocyclic group, etc.; W represents —CO—, —CO—CO—, —CO—NH—, —CS—NH—, or —SO 2 —, or a cannabinoid-receptor agonist comprising said imine compound as an active ingredient. The imine compound of the present invention has a cannabinoid-receptor agonist effect, and is useful as a therapeutic or prophylactic drug for pains and autoimmune diseases.

  一种以以下式表示的亚胺化合物：其中A代表杂环基团；R1、R2和R3分别表示氢原子、卤素原子、C1-10烷基，该烷基可选地取代有芳基，所述芳基取代有卤素原子，C3-10环烷基，C1-6卤代烷基，C1-10烷氧基等；R4表示可选地取代的C1-10烷基，C2-6烯基或芳基；R5表示氢原子，C1-10烷氧基，C1-6卤代烷基，可选地取代的C1-10烷基或C2-6烯基，可选地取代的芳基或杂环基团等；W表示—CO—，—CO—CO—，—CO—NH—，—CS—NH—或—SO2—，或以该亚胺化合物为活性成分的大麻素受体激动剂。本发明的亚胺化合物具有大麻素受体激动剂作用，可用作治疗或预防疼痛和自身免疫性疾病的药物。
• Macrolides
  申请人：Pfizer Products Inc.

  公开号：EP2233493A1

  公开（公告）日：2010-09-29

  Pharmaceutically acceptable salts of macrolide compounds of the formula (I) as shown below and defined herein, and their use, e.g., as antibacterial and antiprotazoal agents in animals, including humans.

  如下文所示并在此定义的式(I)大环内酯化合物的药学上可接受的盐，以及它们在动物（包括人类）中作为抗菌剂和抗原唑剂等的用途。
• MACROLIDES
  申请人：Pfizer Products Inc.

  公开号：EP1836211B1

  公开（公告）日：2010-03-03