异克罗米 | 57009-15-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 中文名称: 异克罗米
• 中文别名: 异克洛米
• 英文名称: 6-carboxy-2'-isopropoxy-flavone
• 英文别名: isocromil；2-(2-isopropoxy-phenyl)-4-oxo-4H-chromene-6-carboxylic acid；4-oxo-2-(2-propan-2-yloxyphenyl)chromene-6-carboxylic acid
• CAS: 57009-15-1
• 化学式: C₁₉H₁₆O₅
• 分子量: 324.333
• InChiKey: YLQMFQKRHQCFBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(2-isopropoxy-phenyl)-4-oxo-4H-chromene-6-carboxylic acid methyl ester 、 氢氧化钾 以78%的产率得到
  参考文献：
  名称：

  DORIA G.; ROMEO C.; GIRALDI P.; LAURIA F.; SBERZE P.; TIBOLLA M.; CORNO M+, EUR. J. MED. CHEM., 1978, 13, NO 1, 33-39

  摘要：

  DOI：

文献信息

• 7-carboxy-flavone derivatives preparation method and therapeutic use
  申请人：——

  公开号：US20040059136A1

  公开（公告）日：2004-03-25

  The invention concerns novel flavone and isoflavone derivatives of formulae (Ia) and (Ib) wherein: X represents a group of formula —COOR, or —PO(OR) 2 ; R represents a hydrogen atom or an alkaline or alkaline-earth metal, or a lower alkyl group; R 1 represents a hydroxy group, a lower alkoxy group or an acyloxy group; R 2 and R 3 , identical or different, represent a hydrogen or halogen atom, or a trifluoromethyl group, a trichloromethyl group, a hydroxy group, an alkoxy group or an acyloxy group comprising 1 to 5 carbon atoms, or R 2 and R 3 can combine to form an alkylene dioxy group. The invention is useful for rheumatic diseases. 1

  该发明涉及具有以下式(Ia)和(Ib)的新型黄酮和异黄酮衍生物：其中：X代表式—COOR或—PO(OR)2的基团；R代表氢原子或碱金属或碱土金属，或低碳基；R1代表羟基、低碳氧基或酰氧基；R2和R3，相同或不同，代表氢原子或卤素原子，或三氟甲基基团、三氯甲基基团、羟基、烷氧基或含有1至5个碳原子的酰氧基，或R2和R3可以结合形成烷二氧基基团。该发明对风湿病有用。
• Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
  申请人：Scaramuzzino, Giovanni

  公开号：EP1336602A1

  公开（公告）日：2003-08-20

  New pharmaceutical compounds of general formula (I): F-(X)q where q is an integer from 1 to 5, preferably 1; -F is chosen among drugs described in the text, -X is chosen among 4 groups -M, -T, -V and -Y as described in the text. The compounds of general formula (I) are nitrate prodrugs which can release nitric oxide in vivo in a controlled and selective way and without hypotensive side effects and for this reason they are useful for the preparation of medicines for prevention and treatment of inflammatory, ischemic, degenerative and proliferative diseases of musculoskeletal, tegumental, respiratory, gastrointestinal, genito-urinary and central nervous systems.

  通式（I）的新药物化合物：F-（X）q，其中q是1到5的整数，最好是1；-F是在文本中描述的药物中选择的，-X是在文本中描述的4个组-M，-T，-V和-Y中选择的。通式（I）的化合物是硝酸盐前药，可以在体内以受控和选择性的方式释放一氧化氮，而不会产生降压副作用，因此它们非常适用于制备用于预防和治疗肌肉骨骼，皮肤，呼吸，消化，泌尿和中枢神经系统的炎症，缺血，退行性和增生性疾病的药物。
• 5:6-Benzo-.gamma.-pyrone derivatives and process for their preparation
  申请人：Carlo Erba S.p.A.

  公开号：US04148900A1

  公开（公告）日：1979-04-10

  Chromone compounds carrying a pyridyl substituent at the 2-position are disclosed, such as, for instance, 6-carboxy-2-(2'-pyridyl)-chromone. The disclosed compounds are useful in the treatment of allergies.

  本文披露了在2-位置携带吡啶基团的Chromone化合物，例如6-羧基-2-(2'-吡啶基)-Chromone。这些化合物在过敏治疗中非常有用。
• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Pharmaceutical composition containing 5:6-benzo-alpha-pyrone derivatives
  申请人：Carlo Erba, S.p.A.

  公开号：US04083953A1

  公开（公告）日：1978-04-11

  A pharmaceutical composition, and method of treating allergic conditions therewith, is disclosed, wherein said composition contains a 5:6-benzo-.gamma.-pyrone derivative, such as, for instance, 6-carboxy-2'-isopropoxy-flavone. The composition may be used to treat various allergic conditions, including bronchial asthma, allergic rhinitis, hay fever, urticaria and dermatosis.

  本发明涉及一种药物组合物及其治疗过敏症的方法，其中所述组合物包含5:6-苯并.γ.-吡喃衍生物，例如6-羧基-2'-异丙氧基-黄酮。该组合物可用于治疗各种过敏症，包括支气管哮喘、过敏性鼻炎、花粉热、荨麻疹和皮肤病。