diazidomethane | 107585-03-5

• 分子结构分类: 有机化合物 - 有机盐 - 有机叠氮化物
• 英文名称: diazidomethane
• 英文别名: Diazidomethan；Methylene azide
• CAS: 107585-03-5
• 化学式: CH₂N₆
• 分子量: 98.0671
• InChiKey: WBUWDDRQOFKUGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  28.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  DPA 101 、 diazidomethane 在 copper(II) sulfate 、 sodium ascorbate 作用下， 以 乙醇 为溶剂， 生成 2-[4-[[1-(azidomethyl)triazol-4-yl]methoxy]phenyl]-6-(4-methylpiperazin-1-yl)-1H-benzimidazole
  参考文献：
  名称：

  Recognition of HIV-TAR RNA using neomycin–benzimidazole conjugates

  摘要：

  Synthesis of a novel class of compounds and their biophysical studies with TAR-RNA are presented. The synthesis of these compounds was achieved by conjugating neomycin, an aminoglycoside, with benzimidazoles modeled from a B-DNA minor groove binder, Hoechst 33258. The neomycin-benzimidazole conjugates have varying linkers that connect the benzimidazole and neomycin units. The linkers of varying length (5-23 atoms) in these conjugates contain one to three triazole units. The UV thermal denaturation experiments showed that the conjugates resulted in greater stabilization of the TAR-RNA than either neomycin or benzimidazole used in the synthesis of conjugates. These results were corroborated by the FID displacement and tat-TAR inhibition assays. The binding of ligands to the TAR-RNA is affected by the length and composition of the linker. Our results show that increasing the number of triazole groups and the linker length in these compounds have diminishing effect on the binding to TAR-RNA. Compounds that have shorter linker length and fewer triazole units in the linker displayed increased affinity towards the TAR RNA. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.08.014
• 作为产物：
  描述：

  二溴甲烷 在 polymeric ammonium azide 作用下， 以 四氢呋喃 为溶剂， 反应 384.0h， 以60%的产率得到diazidomethane
  参考文献：
  名称：

  Hassner, Alfred; Stern, Meir, Angewandte Chemie, 1986, vol. 98, # 5, p. 479 - 480

  摘要：

  DOI：

文献信息

• 一种链双1,2,3-三唑罗丹明6G类荧光探针及 其制备与应用
  申请人：浙江工业大学

  公开号：CN108424419B

  公开（公告）日：2020-10-27

  本发明公开了一种链双1,2,3‑三唑罗丹明6G类荧光探针及其制备与应用，本发明合成的探针对Fe3+具有高效专一的选择性，可通过颜色变化和荧光变化来识别Fe3+，可以应用于环境水样中的Fe3+的检测。本发明探针方法测定三价铁离子浓度具有误差小、灵敏度高、准确度高等特点，尤其在低浓度的三价铁离子，更显示出优越的灵敏度和准确度。本发明设计合成的探针的特色之处在于受体合成路线短，简单易操作，并且对Fe3+的识别效果理想，将其定性应用于环境水样中初步Fe3+的检测，也可以定量来测定水样中的Fe3+。将来可将其进一步应用于环境和生物系统中对Fe3+的检测。
• Photochemistry of Ru(II) Triazole Complexes with 6-Membered Chelate Ligands: Detection and Reactivity of Ligand-Loss Intermediates
  作者：Katie Eastham、Aaron D. W. Kennedy、Synøve Ø. Scottwell、Jack E. Bramham、Samantha Hardman、Alexander P. Golovanov、Paul A. Scattergood、James D. Crowley、Paul I. P. Elliott

  DOI：10.1021/acs.inorgchem.4c00251

  日期：2024.5.20

  Photochemical ligand release from metal complexes may be exploited in the development of novel photoactivated chemotherapy agents for the treatment of cancer and other diseases. Highly intriguing photochemical behavior is reported for two ruthenium(II) complexes bearing conformationally flexible 1,2,3-triazole-based ligands incorporating a methylene spacer to form 6-membered chelate rings. [Ru(bpy)2(pictz)]2+

  金属配合物释放的光化学配体可用于开发用于治疗癌症和其他疾病的新型光活化化疗剂。据报道，两种钌 (II) 配合物具有非常有趣的光化学行为，这些配合物带有构象灵活的 1,2,3-三唑基配体，并结合亚甲基间隔基以形成 6 元螯合环。 [Ru(bpy) 2 (pictz)] 2+ ( 1 ) 和 [Ru(bpy) 2 (btzm)] 2+ ( 2 ) (bpy = 2,2′-联吡啶；pictz = 1-(吡啶基)-4 -苯基-1,2,3-三唑；btzm = 双(4-苯基-1,2,3-三唑-4-基)甲烷) 通过三唑环通过碱性较低的 N2 原子进行螯合并且在乙腈溶液中很容易发生 pictz 和 btzm 配体（分别为 phi = 0.079 和 0.091）的光化学释放，在两种情况下形成cis -[Ru(bpy) 2 (NCMe) 2 ] 2+ ( 3 )。 [Ru(bpy) 2 (κ 1 -pictz
• Synthesis of azidochloromethane and azidobromomethane
  作者：Klaus Banert、Young-Hyuk Joo、Tobias Rüffer、Bernhard Walfort、Heinrich Lang

  DOI：10.1016/j.tetlet.2010.03.094

  日期：2010.5

  By treatment of tris(azidomethyl)amine with dry hydrogen halide, azidochloromethane and azidobromomethane were prepared. The former product, which is more stable than the latter, was isolated as a colorless liquid. The desired azidohalomethanes are intermediates in the nucleophilic substitution of dihalomethanes to generate diazidomethane but could not be detected in this transformation. (C) 2010 Elsevier Ltd. All rights reserved.
• Synthetic methods. 33. Utility of a polymeric azide reagent in the formation of di- and triazidomethane. Their NMR spectra and the x-ray structure of derived triazoles
  作者：Alfred Hassner、Meir Stern、Hugo E. Gottlieb、Felix Frolow

  DOI：10.1021/jo00295a014

  日期：1990.4
• HASSNER A.; STERN M., ANGEW. CHEM., 98,(1986) N 5, 479-480
  作者：HASSNER A.、 STERN M.

  DOI：——

  日期：——