azotriethyleneoxydodecane disulfide | 860305-03-9

• 分子结构分类: 有机化合物 - 有机盐 - 有机叠氮化物
• 英文名称: azotriethyleneoxydodecane disulfide
• 英文别名: 1-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]-12-[12-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]dodecyldisulfanyl]dodecane；1-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-12-[12-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]dodecyldisulfanyl]dodecane
• CAS: 860305-03-9
• 化学式: C₃₆H₇₂N₆O₆S₂
• 分子量: 749.136
• InChiKey: DRBPOAXNVKMCHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.2
• 重原子数：
  50
• 可旋转键数：
  45
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  135
• 氢给体数：
  0
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  azotriethyleneoxydodecane disulfide 在 三苯基膦 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 24.0h， 生成 2-(2-{2-[12-(12-{2-[2-(2-Amino-ethoxy)-ethoxy]-ethoxy}-dodecyldisulfanyl)-dodecyloxy]-ethoxy}-ethoxy)-ethylamine
  参考文献：
  名称：

  New syntheses for 11-(mercaptoundecyl)triethylene glycol and mercaptododecyltriethyleneoxy biotin amide

  摘要：

  Novel syntheses for mercaptododecyltriethyleneoxy biotin amide and 11-(mercaptoundecyl)triethylene glycol are presented here. Such alkyl thiols are popular components in creating monolayers capable of specifically binding proteins. The development of a variety of functionalized alkyl thiol compounds has a great impact on biosensor substrate design. In our synthesis of mercaptododecyltriethylencoxy biotin amide, we couple aminotriethyleneoxydodecane disulfide to the NHS-activated biotin; this technique is amenable to attaching a carboxylated molecule of interest in order to create the functionalized alkyl thiol of choice. The 11-(mercaptoundecyl)triethylene glycol synthesis presented here is an alternative method easily completed in three steps. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.04.091
• 作为产物：
  描述：

  12-(azotriethyleneoxy)-1-bromododecane 在 硫脲 、 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 22.0h， 以46%的产率得到azotriethyleneoxydodecane disulfide
  参考文献：
  名称：

  New syntheses for 11-(mercaptoundecyl)triethylene glycol and mercaptododecyltriethyleneoxy biotin amide

  摘要：

  Novel syntheses for mercaptododecyltriethyleneoxy biotin amide and 11-(mercaptoundecyl)triethylene glycol are presented here. Such alkyl thiols are popular components in creating monolayers capable of specifically binding proteins. The development of a variety of functionalized alkyl thiol compounds has a great impact on biosensor substrate design. In our synthesis of mercaptododecyltriethylencoxy biotin amide, we couple aminotriethyleneoxydodecane disulfide to the NHS-activated biotin; this technique is amenable to attaching a carboxylated molecule of interest in order to create the functionalized alkyl thiol of choice. The 11-(mercaptoundecyl)triethylene glycol synthesis presented here is an alternative method easily completed in three steps. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.04.091

文献信息

• New syntheses for 11-(mercaptoundecyl)triethylene glycol and mercaptododecyltriethyleneoxy biotin amide
  作者：Christie A. Canaria、Jeffrey O. Smith、C.J. Yu、Scott E. Fraser、Rusty Lansford

  DOI：10.1016/j.tetlet.2005.04.091

  日期：2005.7

  Novel syntheses for mercaptododecyltriethyleneoxy biotin amide and 11-(mercaptoundecyl)triethylene glycol are presented here. Such alkyl thiols are popular components in creating monolayers capable of specifically binding proteins. The development of a variety of functionalized alkyl thiol compounds has a great impact on biosensor substrate design. In our synthesis of mercaptododecyltriethylencoxy biotin amide, we couple aminotriethyleneoxydodecane disulfide to the NHS-activated biotin; this technique is amenable to attaching a carboxylated molecule of interest in order to create the functionalized alkyl thiol of choice. The 11-(mercaptoundecyl)triethylene glycol synthesis presented here is an alternative method easily completed in three steps. (c) 2005 Elsevier Ltd. All rights reserved.