| 1257225-39-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1257225-39-0
• 化学式: C₈H₁₂N₂O₃
• 分子量: 184.195
• InChiKey: QMVAYBCTJXLMBE-UHFFFAOYSA-N

物化性质

• 沸点：
  400.7±35.0 °C(Predicted)
• 密度：
  1.264±0.06 g/cm3(Predicted)

反应信息

• 作为产物：
  描述：

  重氮乙酸乙酯 、 3-丁炔-1-醇 以 甲苯 为溶剂， 反应 4.0h， 生成 ethyl 3-hydroxyethyl-1H-pyrazole-5-carboxylate 、
  参考文献：
  名称：

  A facile synthesis of pyrazoles with multi-point structural diversity by 1,3-dipolar cycloaddition

  摘要：

  We describe the synthesis of diverse pyrazoles by 1,3-dipolar cycloaddition of ethyl diazoacetate with various acetylenes in refluxing toluene. The product pyrazoles are useful starting points for preparing a diverse collection of trisubstituted pyrazole carboxamides. For aryl and heteroaryl alkynes a single product is obtained while alkyl alkynes afford a ca. 6:1 mixture of regioisomers. The observed regioselectivity for the cycloaddition step and the ease of reaction are consistent with predictions derived from computing the HOMO-LUMO energies of the reactants. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2010.09.012