3-Nitro-5-phenyl-pyrazol | 38858-87-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-Nitro-5-phenyl-pyrazol
• 英文别名: 5-nitro-3-phenyl-1H-pyrazole
• CAS: 38858-87-6
• 化学式: C₉H₇N₃O₂
• 分子量: 189.173
• InChiKey: CALDFXAYVDKUEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-Nitro-5-phenyl-pyrazol 、 硫酸二甲酯 、 甲醇 生成 1-methyl-3-nitro-5-phenylpyrazole
  参考文献：
  名称：

  GRIMMETT M. R.; LIM K. H. R.; WEAVERS R. T., AUSTRAL. J. CHEM., 1979, 32, NO 10, 2203-2213

  摘要：

  DOI：

文献信息

• COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY
  申请人：IFM Due, Inc.

  公开号：EP3818044A1

  公开（公告）日：2021-05-12
• [EN] COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY<br/>[FR] COMPOSÉS ET COMPOSITIONS POUR TRAITER DES ÉTATS PATHOLOGIQUES ASSOCIÉS À UNE ACTIVITÉ DE STING
  申请人：IFM DUE INC

  公开号：WO2020150417A2

  公开（公告）日：2020-07-23

  This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.