| 1415122-99-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• CAS: 1415122-99-4
• 化学式: C₁₃H₁₃IN₂O₄
• 分子量: 388.162
• InChiKey: NKYHCVPTSOICOA-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  Ditert-butyl pyrazolo[1,5-a]pyridine-2,3-dicarboxylate 在 bis(2,2,6,6-tetramethylpiperidinyl)zinc, lithium chloride, magnesium chloride complex 、 碘 作用下， 以 四氢呋喃 为溶剂， 生成 、
  参考文献：
  名称：

  Synthesis of 7-trifluoromethylpyrazolo[1,5-a]pyridinedicarboxylate

  摘要：

  Two syntheses of 7-trifluoromethylpyrazolo[1,5-a]pyridine dicarboxylate have been described. Approach A utilizes a nucleophilic addition of a trifluoromethyl group to N-p-toluenesulfonyliminopyridinium ylide followed by aromatization and subsequent cycloaddition with diethyl acetylenedicarboxylate to give 1b in modest yield. Approach B involves a selective zincation of pyrazolopyridine dicarboxylate at the C-7 position with (TMP)(2)Zn center dot 2LiCl.2MgCl(2) followed by iodination and trifluoromethylation to give 1b in good yield. The process in approach B has been successfully demonstrated on scale. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.09.136