4-Benzamino-5-benzoyloxy-3-methyl-1-phenyl-pyrazol | 102665-79-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-Benzamino-5-benzoyloxy-3-methyl-1-phenyl-pyrazol
• 英文别名: 5-Benzoyloxy-4-benzamino-3-methyl-1-phenyl-pyrazol；4-benzoylamino-5-benzoyloxy-3-methyl-1-phenyl-1H-pyrazole；4-Benzoylamino-5-benzoyloxy-3-methyl-1-phenyl-1H-pyrazol
• CAS: 102665-79-2
• 化学式: C₂₄H₁₉N₃O₃
• 分子量: 397.433
• InChiKey: OCGRYGGRNUQGOA-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  苯甲酰氯 、 alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 作用下， 生成 4-Benzamino-5-benzoyloxy-3-methyl-1-phenyl-pyrazol
  参考文献：
  名称：

  Have the Oldest Old Adults Ever Been Frail in the Past? A Hypothesis That Explains Modern Trends in Survival

  摘要：

  Three important results concerning the shape and the trends of the human mortality rate were discussed recently in demographic and epidemiological literature. These are the deceleration of the mortality rate at old ages, the tendency to rectangularization of the survival curve, and the decline of the old age mortality observed in the second part of the 20th century. In this paper we show that all these results can be explained by using a model with a new type of heterogeneity associated with individual differences in adaptive capacity. We first illustrate the idea of such a model by considering survival in a mixture of two subpopulations of individuals (called "labile" and "stable"). These subpopulations are characterized by different Gompertz mortality patterns, such that their mortality rates cross over. The survival chances of individuals in these subpopulations have different sensitivities to changes in environmental conditions. Then we develop a more comprehensive model in which the mortality rate is related to the adaptive capacity of an organism. We show that the trends in survival patterns experienced by a mixture of such individuals resemble those obtained in an analysis of empirical data on survival in developed countries. Lastly, we present evidence of the existence of subpopulations of phenotypes in both humans and experimental organisms, which were used as prototypes in our models. The existence of such phenotypes provides the possibility that at least part of today's centenarians originated from an initially frail part of the cohort.

  DOI：

  10.1093/gerona/56.10.b432