4-(((3-Mercapto-5-(2-methoxyphenyl)-4H-1,2,4-triazol-4-yl)imino)methyl)phenol | 478256-98-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(((3-Mercapto-5-(2-methoxyphenyl)-4H-1,2,4-triazol-4-yl)imino)methyl)phenol
• 英文别名: 4-[(E)-(4-hydroxyphenyl)methylideneamino]-3-(2-methoxyphenyl)-1H-1,2,4-triazole-5-thione
• CAS: 478256-98-3
• 化学式: C₁₆H₁₄N₄O₂S
• 分子量: 326.4
• InChiKey: POPXXFBTWMZRSB-LICLKQGHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Universal one-pot and up-scalable synthesis of SERS encoded nanoparticles
  申请人：Medcom Advance, S.A

  公开号：US10150160B2

  公开（公告）日：2018-12-11

  The universal one-pot and up-scalable synthesis of SERS encoded nanoparticles relies on the controlled co-absorption of mercaptoundecanoic acid (MUA) and the Raman code on the metallic surfaces of the nanoparticles. In contrast to most of the reported procedures which typically involve complex steps, the present method has demonstrated to be an easy and fast one-pot approach for the production of SERS-encoded nanoparticles. This versatile strategy allows for the SERS codification of particles with every molecule with affinity toward the metal surface, independently of its chemical nature, as exemplified here in the fabrication of 31 different encoded particles using the same standard procedure. In addition to the easiness of preparation, scalability to the liter regime, stability in aqueous solutions including PBS and chemical diversity, our SERS-encoded particles show considerably higher optical efficiency than those fabricated by using PEG or PVP polymers.

  SERS 编码纳米粒子的通用单锅可放大合成方法依赖于纳米粒子金属表面对巯基十一酸（MUA）和拉曼代码的可控共吸收。与大多数通常涉及复杂步骤的报告程序相比，本方法已证明是一种简单、快速的一锅式 SERS 编码纳米粒子生产方法。这种多用途的策略可以将每一种对金属表面具有亲和力的分子进行 SERS 编码，而不管其化学性质如何，在这里使用相同的标准程序制备出 31 种不同的编码颗粒就是一个例子。我们的 SERS 编码颗粒不仅制备简单、可扩展到升浓度、在水溶液（包括 PBS）中稳定，而且化学性质多样，与使用 PEG 或 PVP 聚合物制备的颗粒相比，我们的 SERS 编码颗粒显示出更高的光学效率。
• UNIVERSAL ONE-POT AND UP-SCALABLE SYNTHESIS OF SERS ENCODED NANOPARTICLES
  申请人：MEDCOM ADVANCE, S.A.

  公开号：EP3227037A1

  公开（公告）日：2017-10-11
• METHOD FOR MANUFACTURING SURFACE ENHANCED RAMAN SPECTROSCOPY TAGS
  申请人：Sicpa Holding SA

  公开号：EP3999834A1

  公开（公告）日：2022-05-25
• [EN] UNIVERSAL ONE-POT AND UP-SCALABLE SYNTHESIS OF SERS ENCODED NANOPARTICLES<br/>[FR] SYNTHÈSE UNIVERSELLE EN ENCEINTE UNIQUE ET POUVANT ÊTRE DÉVELOPPÉE À GRANDE ÉCHELLE DE NANOPARTICULES CODÉES DRES
  申请人：MEDCOM ADVANCE S A

  公开号：WO2016086999A1

  公开（公告）日：2016-06-09

  The universal one-pot and up-scalable synthesis of SERS encoded nanoparticles relies on the controlled co-absorption of mercaptoundecanoic acid (MUA) and the Raman code on the metallic surfaces of the nanoparticles. In contrast to most of the reported procedures which typically involve complex steps, the present method has demonstrated to be an easy and fast one-pot approach for the production of SERS-encoded nanoparticles. This versatile strategy allows for the SERS codification of particles with every molecule with affinity toward the metal surface, independently of its chemical nature, as exemplified here in the fabrication of 3 different encoded particles using the same standard procedure. In addition to the easiness of preparation, scalability to the liter regime, stability in aqueous solutions including PBS and chemical diversity, our SERS-encoded particles show considerably higher optical efficiency than those fabricated by using PEG or PVP polymers.
• [EN] METHOD FOR MANUFACTURING SURFACE ENHANCED RAMAN SPECTROSCOPY TAGS<br/>[FR] PROCÉDÉ DE FABRICATION D'ÉTIQUETTES DE SPECTROSCOPIE RAMAN EXALTÉE DE SURFACE
  申请人：SICPA HOLDING SA

  公开号：WO2021009090A1

  公开（公告）日：2021-01-21

  The present invention relates to the field of methods of manufacturing of surface enhanced Raman spectroscopy (SERS) tags. The manufacturing method according to the present invention is reproducible and versatile and enables the production in an expedient manner of high quantities of SERS tags characterized by a narrow size distribution and a high ratio of low-number aggregates. SERS tags manufactured by the inventive manufacturing method described herein provide increased ensemble SERS responses.