5-(morpholinomethyl)-2-phenylthiazole-4-carboxylic acid hydrochloride | 1231952-85-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(morpholinomethyl)-2-phenylthiazole-4-carboxylic acid hydrochloride
• 英文别名: 5-(Morpholin-4-ylmethyl)-2-phenyl-1,3-thiazole-4-carboxylic acid;hydrochloride
• CAS: 1231952-85-4
• 化学式: C₁₅H₁₆N₂O₃S*ClH
• 分子量: 340.831
• InChiKey: SZFLAJWRLWTJBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.76
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  90.9
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] THIAZOLOPYRIDINE SIRTUIN MODULATING COMPOUNDS<br/>[FR] COMPOSÉS THIAZOLOPYRIDINES DE MODULATION DES SIRTUINES
  申请人：SIRTRIS PHARMACEUTICALS INC

  公开号：WO2010071853A1

  公开（公告）日：2010-06-24

  Provided herein are novel sirtuin-modulating compounds of Structural Formula (Ia) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本文提供了结构式（Ia）的新型sirtuin调节化合物及其使用方法。这些sirtuin调节化合物可用于延长细胞寿命，并治疗和/或预防各种疾病和紊乱，包括与衰老或压力、糖尿病、肥胖、神经退行性疾病、心血管疾病、血液凝块紊乱、炎症、癌症和/或潮红有关的疾病或紊乱，以及那些会受益于增加线粒体活性的疾病或紊乱。还提供了包含sirtuin调节化合物与另一治疗剂组合的组合物。
• THIAZOLOPYRIDINE SIRTUIN MODULATING COMPOUNDS
  申请人：Oalmann Christopher

  公开号：US20110306609A1

  公开（公告）日：2011-12-15

  Provided herein are novel sirtuin-modulating compounds of Structural Formula (Ia) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本文提供了结构式（Ia）的新型Sirtuin调节化合物及其使用方法。这些Sirtuin调节化合物可用于延长细胞寿命，并治疗和/或预防各种疾病和疾病，包括与衰老或压力有关的疾病或疾病，糖尿病，肥胖症，神经退行性疾病，心血管疾病，血液凝块性疾病，炎症，癌症和/或潮红，以及从中受益的疾病或疾病增加线粒体活性。还提供了包含Sirtuin调节化合物与另一种治疗剂组合的组合物。
• US8343997B2
  申请人：——

  公开号：US8343997B2

  公开（公告）日：2013-01-01
• US8492401B2
  申请人：——

  公开号：US8492401B2

  公开（公告）日：2013-07-23