n-Boc-hexafluorovaline | 1098184-03-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: n-Boc-hexafluorovaline
• 英文别名: (2S)-4,4,4-trifluoro-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(trifluoromethyl)butanoic acid
• CAS: 1098184-03-2
• 化学式: C₁₀H₁₃F₆NO₄
• 分子量: 325.208
• InChiKey: ADHFSDGXBRYNQG-BYPYZUCNSA-N

物化性质

• 沸点：
  310.5±42.0 °C(Predicted)
• 密度：
  1.389±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  n-Boc-hexafluorovaline 在 盐酸 、 4-(4,6-二甲氧基三嗪-2-基)-4-甲基吗啉盐酸盐 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 、 乙酸乙酯 为溶剂， 反应 22.5h， 生成
  参考文献：
  名称：

  Methyl to trifluoromethyl substitution as a strategy to increase the membrane permeability of short peptides

  摘要：

  CH₃到CF₃的取代会增加蛋白质氨基酸侧链的膜通透性。

  DOI：

  10.1039/d1ob01565f
• 作为产物：
  描述：

  N^α-(tert-butyloxycarbonyl)-DL-hexafluorovaline 在 溶剂黄146 作用下， 以 正己烷 、 异丙醇 为溶剂， 生成 n-Boc-hexafluorovaline
  参考文献：
  名称：

  Methyl to trifluoromethyl substitution as a strategy to increase the membrane permeability of short peptides

  摘要：

  CH₃到CF₃的取代会增加蛋白质氨基酸侧链的膜通透性。

  DOI：

  10.1039/d1ob01565f

文献信息

• Synthesis of [Hexafluorovalyl^1,1′]gramicidin S
  作者：Toru Arai、Takashi Imachi、Tamaki Kato、H. Iyehara Ogawa、Tsutomu Fujimoto、Norikazu Nishino

  DOI：10.1246/bcsj.69.1383

  日期：1996.5

  [Hexafluorovalyl1,1′]gramicidin S (8), in which two valine residues in the natural gramicidin S were replaced by L-hexafluorovaline (Hfv) residues, was synthesized by the solid-phase-synthesis and cyclization-cleavage method on benzophenone oxime resin. Though the racemic hexafluorovaline derivative was employed for the peptide synthesis, the desired product was isolated in moderate yield, probably

  [Hexafluorovalyl1,1']短杆菌肽S(8)，其中天然短杆菌肽S中的两个缬氨酸残基被L-六氟缬氨酸(Hfv)残基取代，通过固相合成和环化-裂解法在二苯甲酮肟上合成树脂。虽然外消旋六氟缬氨酸衍生物用于肽合成，但以中等收率分离了所需产物，可能反映了 8 的稳定环状结构。 CD 和 1H NMR 谱表明 8 的构象与短杆菌肽 S 的构象相似。尽管引入了六氟缬氨酸残基，但仍保持了两个β-转角结构和具有四个分子内氢键的反平行β-折叠结构。
• Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：Thompson C. Richard

  公开号：US20050267150A1

  公开（公告）日：2005-12-01

  Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  本发明涉及一种抑制β-淀粉样肽释放和/或其合成的化合物，据此，该化合物在治疗阿尔茨海默病方面具有用途。本发明还涉及包括抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物，以及使用这种药物组合物在预防和治疗阿尔茨海默病方面的方法。
• Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting &bgr;-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：Elan Pharmaceutials, Inc.

  公开号：US06569851B1

  公开（公告）日：2003-05-27

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  本发明涉及一种抑制β-淀粉样肽的释放和/或合成的化合物，因此在治疗阿尔茨海默病方面具有用途。本发明还涉及包括抑制β-淀粉样肽的释放和/或合成的化合物的药物组合物，以及使用这种药物组合物预防和治疗阿尔茨海默病的方法。
• Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：Thompson Richard C.

  公开号：US06906056B2

  公开（公告）日：2005-06-14

  Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  本发明揭示了抑制β-淀粉样肽释放和/或其合成的化合物，因此具有在治疗阿尔茨海默病方面的用途。还揭示了包括抑制β-淀粉样肽释放和/或其合成的化合物的制药组合物，以及使用这种制药组合物预防和治疗阿尔茨海默病的方法。
• ANTIVIRAL COMPOUNDS
  申请人：Cottell Jeromy J.

  公开号：US20140051626A1

  公开（公告）日：2014-02-20

  The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  该发明涉及抗病毒化合物、含有这种化合物的组合物、包括给予这种化合物的治疗方法，以及用于制备这种化合物的过程和中间体。