(2S)-2-(2,4-difluorophenyl)-2-[(tetrahydropyran-2-yloxy)methyl]oxirane | 310882-23-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S)-2-(2,4-difluorophenyl)-2-[(tetrahydropyran-2-yloxy)methyl]oxirane
• CAS: 310882-23-6
• 化学式: C₁₄H₁₆F₂O₃
• 分子量: 270.276
• InChiKey: OENWZOYKBSGRSS-KZUDCZAMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.73
• 重原子数：
  19.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  30.99
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (2S)-2-(2,4-difluorophenyl)-2-[(tetrahydropyran-2-yloxy)methyl]oxirane 在 sodium tetrahydroborate 、 sodium hydride 、 二甲基亚砜 、 三乙胺 、 lithium chloride 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 89.5h， 生成 (4R)-5-benzyloxy-4-(2,4-difluorophenyl)-2-hydroxymethyl-1,4-pentanediol
  参考文献：
  名称：

  Design and synthesis of potential inhibitors of the ergosterol biosynthesis as antifungal agents

  摘要：

  A series of azolylmethyloxolane derivatives with modified sterol side-chain structures, designed as potential dual functional inhibitors of cytochrome P450 14 alpha-demethylase (14DM) and Delta(24)-sterol methyltransferase (24-SMT) based on the common characteristic features of 24-aminosterols and azole antifungal agents, were synthesized and evaluated for their antifungal activities and inhibitory activities of 14DM and 24-SMT. Among these compounds, imidazolylmethyloxolane derivatives 28a and 28b showed potent in vitro antifungal activities comparable to those of itraconazole. However, the in vitro bioactivities have not been linearly translated into in vivo protection data for some unknown reasons. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00177-2
• 作为产物：
  描述：

  3,4-二氢-2H-吡喃 、 [2-(2,4-二氟苯基)环氧乙烷-2-基]甲醇 在 4-甲基苯磺酸吡啶 作用下， 以 二氯甲烷 为溶剂， 以6.22 g的产率得到(2S)-2-(2,4-difluorophenyl)-2-[(tetrahydropyran-2-yloxy)methyl]oxirane
  参考文献：
  名称：

  Design and synthesis of potential inhibitors of the ergosterol biosynthesis as antifungal agents

  摘要：

  A series of azolylmethyloxolane derivatives with modified sterol side-chain structures, designed as potential dual functional inhibitors of cytochrome P450 14 alpha-demethylase (14DM) and Delta(24)-sterol methyltransferase (24-SMT) based on the common characteristic features of 24-aminosterols and azole antifungal agents, were synthesized and evaluated for their antifungal activities and inhibitory activities of 14DM and 24-SMT. Among these compounds, imidazolylmethyloxolane derivatives 28a and 28b showed potent in vitro antifungal activities comparable to those of itraconazole. However, the in vitro bioactivities have not been linearly translated into in vivo protection data for some unknown reasons. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00177-2