3-(4,4-dimethylpent-2-yn-1-yl)oxazolidin-2-one | 1610010-36-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-(4,4-dimethylpent-2-yn-1-yl)oxazolidin-2-one
• CAS: 1610010-36-0
• 化学式: C₁₀H₁₅NO₂
• 分子量: 181.235
• InChiKey: BTCFMHJABNQLQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.49
• 重原子数：
  13.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  29.54
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  3-(4,4-dimethylpent-2-yn-1-yl)oxazolidin-2-one 在 bis(1,5-cyclooctadiene)nickel (0) 、 potassium tert-butylate 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 57.0h， 生成 methyl (E)-4,4-dimethyl-2-[(2-oxo-1,3-oxazolidin-3-yl)methyl]pent-2-enoate
  参考文献：
  名称：

  Nickel(0)-Promoted Carboxylation of Allenamides with Carbon Dioxide via a Nickelalactone Intermediate

  摘要：

  Nickel(0)-promoted carboxylation of N-allenylamides (allenamides) with carbon dioxide proceeded via a nickelalactone intermediate to give beta-amino acid derivatives. It was also found that the regioselectivity at the oxidative addition stage was strongly affected by the substituents on the allene part.

  DOI：

  10.1055/s-0033-1340628
• 作为产物：
  描述：

  2-唑烷酮 、 4,4-dimethylpent-2-ynyl methanesulfonate 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 16.5h， 生成 3-(4,4-dimethylpent-2-yn-1-yl)oxazolidin-2-one
  参考文献：
  名称：

  Nickel(0)-Promoted Carboxylation of Allenamides with Carbon Dioxide via a Nickelalactone Intermediate

  摘要：

  Nickel(0)-promoted carboxylation of N-allenylamides (allenamides) with carbon dioxide proceeded via a nickelalactone intermediate to give beta-amino acid derivatives. It was also found that the regioselectivity at the oxidative addition stage was strongly affected by the substituents on the allene part.

  DOI：

  10.1055/s-0033-1340628

文献信息

• Iridium-catalyzed regioselective hydrosilylation of internal alkynes facilitated by directing and steric effects
  作者：Weiwei Gao、Huan Ding、Tian Yu、Zhen Wang、Shengtao Ding

  DOI：10.1039/d1ob00910a

  日期：——

  Here we reported the iridium-catalyzed hydrosilylation of internal alkynes under simple and mild conditions. The intrinsic functional groups of alkyne substrates were disclosed to be crucial in facilitating both the hydrosilylation process and related regioselectivity owing to their coordination capability towards the iridium catalyst. Utilization of the steric trimethylsilyl-protected trihydroxysilane

  在这里，我们报道了在简单和温和的条件下铱催化的内部炔烃的氢化硅烷化。炔烃底物的本征官能团被认为是促进氢化硅烷化过程和相关区域选择性的关键，因为它们对铱催化剂的配位能力。使用立体三甲基甲硅烷基保护的三羟基硅烷被证明是确保该过程有效进行的另一个关键因素。