methyl 5-bromo-2-phenylpentanoate | 223690-15-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 5-bromo-2-phenylpentanoate
• 英文别名: (+/-)-5-bromo-2-phenyl-valeric acid methyl ester；(+/-)-5-Brom-2-phenyl-valeriansaeure-methylester
• CAS: 223690-15-1
• 化学式: C₁₂H₁₅BrO₂
• 分子量: 271.154
• InChiKey: CQZNBTWOTWTUES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  methyl 5-bromo-2-phenylpentanoate 在 番木鳖碱 、 丙酮 作用下， 生成 (R)-2-phenyl-adipic acid
  参考文献：
  名称：

  Westman, Arkiv foer Kemi, 1958, vol. 12, p. 161,165

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 、 硫酸 作用下， 生成 methyl 5-bromo-2-phenylpentanoate
  参考文献：
  名称：

  Westman, Arkiv foer Kemi, 1958, vol. 12, p. 161,165

  摘要：

  DOI：

文献信息

• Donor–Acceptor Binary Photocatalysis System Illustrated by the Intramolecular Cyclization of a Cyclopropanone Acetal Tethered to Cyclohexen-2-one
  作者：Akira Oku、Toshiyuki Miki、Manabu Abe、Masatoshi Ohira、Tohru Kamada

  DOI：10.1246/bcsj.72.511

  日期：1999.3

  Irradiation of 2-[3-(2-methoxy-1-phenyl-2-TBDMSO-cyclopropyl)-propyl]-2-cyclohexen-1-one (5) in the presence of Mg(ClO4)2 (1 mol equiv) and 9,10-dicyanoanthracene (DCA, 0.5 mol equiv) in acetonitrile formed methyl 5-oxo-1-phenyldecahydro-1-naphthaleneacetate (6) in 63% yield. When pyrene was adopted in place of DCA, the yield of 6 was 38%. The results indicate that the photocyclization of 5 induced by the SET can be catalyzed by both donor- and acceptor-type photocatalysts. Irradiation of a similar substrate, 4-(2-methoxy-1-phenyl-2-TBDMSO-cyclopropyl)butyl 2-naphthyl ketone (21), produced methyl 2-hydroxy-2-(2-naphthyl)-1-phenylcyclohexaneacetate (27) in 13% in the presense of p-dicyanobenzene (0.1 mol equiv) and 8% in its absence.

  对2-[3-(2-甲氧基-1-苯基-2-TBDMSO-环丙基)-丙基]-2-环己烯-1-酮（5）进行照射，在Mg(ClO4)2（1摩尔当量）和9,10-二氰基蒽（DCA，0.5摩尔当量）存在下，于乙腈中生成甲基5-氧代-1-苯基十氢-1-萘酸酯（6），产率为63%。当用芘替代DCA时，6的产率为38%。结果表明，5的光循环化反应通过单电子转移（SET）可被供体和受体类型的光催化剂催化。类似底物4-(2-甲氧基-1-苯基-2-TBDMSO-环丙基)丁基-2-萘酮（21）的照射，在存在对-二氰基苯（0.1摩尔当量）时产生甲基2-羟基-2-(2-萘基)-1-苯基环己烷酸酯（27），产率为13%，而在其缺失时产率为8%。
• TRIPTOLIDE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF
  申请人：Hong Kong Baptist University

  公开号：US20160362691A1

  公开（公告）日：2016-12-15

  Tripyolide-nucleic acid aptamer derivatives, a preparation method and use thereof are shown. The structure of the triptolide-nucleic acid aptamer derivatives is as shown by formula I, wherein the definitions of R 1 -R 7 , G, A, B, M, Z and X are described. The present invention uses a nucleic acid aptamer and triptolide or modified compounds thereof as the starting materials, and introduces a linking group A at the C-14 hydroxyl group, epoxy groups and five-membered ring lactones in triptolide, then connects it to a nucleic acid aptamer B, and obtains the triptolide-nucleic acid aptamer derivatives. The triptolide-nucleic acid aptamer derivatives of the present invention have the characteristics of good targeting, a high anti-cancer activity, low toxicity and side effects, good water solubility and high bioavailability, and the preparation method of the present invention is scientific and reasonable and has a controllable quality and good repeatability, and is thereby suitable for production.
• US9809822B2
  申请人：——

  公开号：US9809822B2

  公开（公告）日：2017-11-07