1,3-bis(1-(2,4-dichlorobenzyl)-1H-1,2,3-triazol-4-yl)benzene | 1385031-89-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,3-bis(1-(2,4-dichlorobenzyl)-1H-1,2,3-triazol-4-yl)benzene
• CAS: 1385031-89-9
• 化学式: C₂₄H₁₆Cl₄N₆
• 分子量: 530.243
• InChiKey: WJXQEFXTPLWPSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.91
• 重原子数：
  34.0
• 可旋转键数：
  6.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  61.42
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  1,3-二乙炔苯 、 2,4-二氯溴苄 以 乙醇 为溶剂， 反应 2.0h， 以91%的产率得到1,3-bis(1-(2,4-dichlorobenzyl)-1H-1,2,3-triazol-4-yl)benzene
  参考文献：
  名称：

  Click synthesis of 1,4-disubstituted-1,2,3-triazoles catalysed by CuO–CeO2 nanocomposite in the presence of amberlite-supported azide

  摘要：

  在存在amberlite-负载叠氮化物的情况下，已使用CuO–CeO2纳米复合物催化合成了高产率的1,4-二取代-1,2,3-三氮唑。该催化剂可以重复使用多次，而不会显著降低其催化活性。

  DOI：

  10.1007/s12039-013-0537-0

文献信息

• Copper iodide nanoparticles on poly(4-vinyl pyridine) as new and green catalyst for multicomponent click synthesis of 1,4-disubstituted-1,2,3-triazoles in water
  作者：Jalal Albadi、Mosadegh Keshavarz、Masoumeh Abedini、Masoumeh Vafaie-nezhad

  DOI：10.1016/j.cclet.2012.05.009

  日期：2012.7

  Poly(4-vinyl pyridine) supported nanoparticle of copper(I) iodide is reported as a green and recyclable catalyst for the regioselective synthesis of 1,4-disubstituted-1H-1,2,3-triazoles from benzyl halides, sodium azide and terminal alkynes in water. This catalyst can be recovered by simple filtration and recycled up to 8 consecutive runs without any loss of its efficiency. (C) 2012 Jalal Albadi. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
• Regioselective synthesis of 1,2,3-triazoles catalyzed over ZnO supported copper oxide nanocatalyst as a new and efficient recyclable catalyst in water
  作者：Jalal Albadi

  DOI：10.17344/acsi.2014.1211

  日期：2015.9.15

  The CuO/ZnO nanocatalysts are reported as efficient and recyclable catalysts for the regioselective synthesis of 1,2,3-triazoles from benzyl halides and terminal alkynes in water. The catalysts are synthesized by a co-precipitation method and characterized by BET surface area, XRD, SEM, TEM and EDS analysis. The effect of CuO loading, catalyst amount and solvent was investigated. The catalyst can be recovered by a simple filtration and applied in consecutive runs with no loss of activity.