LIVNYL | 1182713-99-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: LIVNYL
• 英文别名: H-Leu-Ile-Val-Asn-Tyr-Leu-OH；(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoic acid
• CAS: 1182713-99-0
• 化学式: C₃₆H₅₉N₇O₉
• 分子量: 733.906
• InChiKey: VDFUFJRXOQSBAR-LRLKTANUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  52
• 可旋转键数：
  22
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  272
• 氢给体数：
  9
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  Fmoc-Leu-Wang resin 、 Fmoc-L-缬氨酸 、 Fmoc-L-亮氨酸 、 Fmoc-L-异亮氨酸 、 Fmoc-O-叔丁基-L-酪氨酸 、 Fmoc-N-三苯甲基-L-天冬酰胺 在 哌啶 、 1-羟基苯并三唑 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.17h， 生成 LIVNYL
  参考文献：
  名称：

  Discovery of Small Peptides Derived from Embryonic Lethal Abnormal Vision Proteins Structure Showing RNA-Stabilizing Properties

  摘要：

  Four peptides corresponding to highly conserved motives within the first two RNA recognition motif-type domains of ELAV proteins were prepared. and their effect on the stability of NOVA-1 and VEGF ELAV-target mRNAs Was evaluated. Biological results show that in the presence of phorbol 12-myristate 13-acetate (a PKC activator triggering the ELAV pathway), an equimolar mixture of peptides induces a statistically significant stabilization of the selected transcripts, suggesting a synergic effect of the two stimuli.

  DOI：

  10.1021/jm900741e

文献信息

• Discovery of Small Peptides Derived from Embryonic Lethal Abnormal Vision Proteins Structure Showing RNA-Stabilizing Properties
  作者：Daniela Rossi、Marialaura Amadio、Anna Carnevale Baraglia、Ornella Azzolina、Antonia Ratti、Stefano Govoni、Alessia Pascale、Simona Collina

  DOI：10.1021/jm900741e

  日期：2009.8.27

  Four peptides corresponding to highly conserved motives within the first two RNA recognition motif-type domains of ELAV proteins were prepared. and their effect on the stability of NOVA-1 and VEGF ELAV-target mRNAs Was evaluated. Biological results show that in the presence of phorbol 12-myristate 13-acetate (a PKC activator triggering the ELAV pathway), an equimolar mixture of peptides induces a statistically significant stabilization of the selected transcripts, suggesting a synergic effect of the two stimuli.