2-(tert-Butyl)thiazole-4-carbonitrile | 848555-20-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(tert-Butyl)thiazole-4-carbonitrile
• 英文别名: 2-tert-butyl-1,3-thiazole-4-carbonitrile
• CAS: 848555-20-4
• 化学式: C₈H₁₀N₂S
• 分子量: 166.247
• InChiKey: BZCQPRZOYPBXER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  64.9
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• QUINOLINE DERIVATIVES AS SMO INHIBITORS
  申请人：GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD

  公开号：US20170174703A1

  公开（公告）日：2017-06-22

  Disclosed are quinoline derivatives as hedgehog pathway inhibitors, especially as SMO inhibitors. Compounds of the present invention can be used in treating diseases relating to hedgehog pathway including cancer.
• BISHETEROCYCLIC CARBONYL SUBSTITUTED DIHYDROPYRAZOLE COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF
  申请人：GENFLEET THERAPEUTICS (SHANGHAI) INC.

  公开号：US20220235032A1

  公开（公告）日：2022-07-28

  A substituted dihydropyrazole compound as shown in formula I, which compound has a selective inhibitory effect on RIPK1, and a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof, wherein the definition of each group in the formula is detailed in the description. In addition is a pharmaceutical composition containing the compound, and the use thereof in the preparation of a drug for treating RIPK1-related diseases or conditions.
• US9938292B2
  申请人：——

  公开号：US9938292B2

  公开（公告）日：2018-04-10